44915-39-1

Basic information

• Product Name: (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER
• Synonyms: (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER;N-(2-Cyanoethyl)glycine methyl ester;methyl 2-(2-cyanoethylamino)acetate
• CAS NO: 44915-39-1
• Molecular Formula: C₆H₁₀N₂O₂
• Molecular Weight: 142.1558
• Mol File: 44915-39-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 257 °C at 760 mmHg
• Flash Point: 109.2 °C
• Appearance: /
• Density: 1.066 g/cm³
• PKA: 4.98±0.19(Predicted)
• CAS DataBase Reference: (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER(44915-39-1)
• EPA Substance Registry System: (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER(44915-39-1)

Safety Data

• Hazardous Substances Data: 44915-39-1(Hazardous Substances Data)

Usage

General Description

(2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER is a chemical compound with the molecular formula C5H8N2O2. It is classified as an ester, which is a derivative of carboxylic acid. The compound contains a cyano group, an amino group, and an ethyl group, making it a versatile building block for various synthetic reactions. It is commonly used in the pharmaceutical and chemical industries as a precursor for the synthesis of complex molecules, such as drugs and agrochemicals. Additionally, it can also be used as a reagent in organic synthesis and as a chemical intermediate in the production of other compounds. Overall, (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER has a wide range of applications in the chemical and pharmaceutical industries due to its chemical composition and reactivity.

Upstream product

• 107-13-1 acrylonitrile 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 67-56-1 methanol 
• 3088-42-4 N-(2-cyanoethyl)glycine 

Downstream Products

• 398491-59-3 3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 
• 398495-65-3 3-amino-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester 
• 761443-69-0 5-tert-butyl 1-ethyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate 
• 850997-37-4 ethyl 5-(2,6-diethylphenylcarbamoyl)-3-[4-(4-methylpiperazin-1-yl)benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylate 
• 175463-32-8 3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors

Two series of 3-aminopyrazole compounds including 24 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and 16 pyrazolo[3,4-b]pyridines were synthesized and evaluated against HCT116, A549, and A2780 tumor cell lines. Among them, three compounds were found to have the ideal anti-proliferative activities in vitro. Docking experiments showed that the novel pyrazolo[3,4-b]pyridines share the similar interaction mode with Aurora-A kinase as PHA739358.

Potent and selective aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition

Potent and selective Aurora kinase inhibitors were identified from the combinatorial expansion of the 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole bi-cycle, a novel and versatile scaffold designed to target the ATP pocket of protein kinases. The most potent c