4510-62-7

Basic information

• Product Name: 4-[4-(2-amino-6-methyl-4-oxo-1,4-dihydropyrimidin-5-yl)butyl]benzoic acid
• CAS NO: 4510-62-7
• Molecular Formula: C₁₆H₁₉N₃O₃
• Molecular Weight: 301.3404
• Mol File: 4510-62-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 531.7°C at 760 mmHg
• Flash Point: 275.4°C
• Density: 1.3g/cm³
• Vapor Pressure: 3.9E-12mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 4-[4-(2-amino-6-methyl-4-oxo-1,4-dihydropyrimidin-5-yl)butyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(2-amino-6-methyl-4-oxo-1,4-dihydropyrimidin-5-yl)butyl]benzoic acid(4510-62-7)
• EPA Substance Registry System: 4-[4-(2-amino-6-methyl-4-oxo-1,4-dihydropyrimidin-5-yl)butyl]benzoic acid(4510-62-7)

Safety Data

• Hazardous Substances Data: 4510-62-7(Hazardous Substances Data)

Upstream product

• 125402-84-8 methyl 4-(5-ethoxycarbonyl-6-oxoheptyl)benzoate 
• 124656-56-0 methyl 4-<(4-methylsulfonyloxy)butyl>benzoate 
• 123910-86-1 4-(4-hydroxybut-1-ynyl)benzoic acid methyl ester 
• 123910-88-3 methyl 4-(4-hydroxybut-1-yl)benzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 125402-86-0 methyl 4-<4-(2-amino-4-methyl-6(1H)-oxopyrimidin-5-yl)butyl>benzoate 

Downstream Products

• 125402-92-8 N-<4-<4-(2-amino-4-methyl-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamic acid 
• 125402-90-6 diethyl N-<4-<4-(2-amino-4-methyl-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate 

Relevant articles and documents

A FACILE ROUTE TO "OPEN CHAIN" ANALOGUES OF DDATHF

N-benzoyl>-L-glutamic acid (7-DM-DDATHF, 18) is a representative of a new series of achiral analogues of the potent anticancer agent 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).Members of this "open chain" pyrimidine series, 18, 19, and 20, were synthesized via guanidine cyclization of 6, 7, and 8 to give the pyrimidines 9, 10, and 11.Ester hydrolysis, glutamate coupling and final saponification yielded the target compounds.