45101-25-5

Basic information

• Product Name: α-(N-t-Butyloxycarbonylamino)acrylic acid
• Synonyms: α-(N-t-Butyloxycarbonylamino)acrylic acid
• CAS NO: 45101-25-5
• Molecular Weight: 187.196
• Mol File: 45101-25-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: α-(N-t-Butyloxycarbonylamino)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-(N-t-Butyloxycarbonylamino)acrylic acid(45101-25-5)
• EPA Substance Registry System: α-(N-t-Butyloxycarbonylamino)acrylic acid(45101-25-5)

Safety Data

• Hazardous Substances Data: 45101-25-5(Hazardous Substances Data)

Upstream product

• 56-45-1 L-serin 
• 18595-34-1 tert-butyl fluoroformate 
• 92813-17-7 Methylphosphonsaeure-O-4-(9-acridinyl)butyl-O'-(N-t-butyloxycarbonyl)serinester 
• 1446512-91-9 (S)-N-((2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropoxy)carbonyl)-3-phenylsydnonimine 
• 889459-00-1 4(S)-benzyl-3-tert-butyl-1,2,3-oxathiazolidine-3,4-dicarboxylate-2,2-dioxide 
• 59524-02-6 N-tert-butoxycarbonyl-L-serine benzyl ester 
• 1620620-04-3 3(S)-(tert-butoxycarbonyl)-1,2,3-oxathiazolidine-4-carboxylicacid-2,2-dioxide 
• 120341-32-4 N-t-butyloxycarbonyl-DL-aspartic acid 

Downstream Products

• 74158-34-2 (1-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-ethylcarbamoyl}-vinyl)-carbamic acid tert-butyl ester 
• 74158-35-3 (S)-2-(2-tert-Butoxycarbonylamino-acryloylamino)-propionic acid (S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl ester 
• 74158-36-4 (S)-2-(2-tert-Butoxycarbonylamino-acryloylamino)-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 87053-93-8 Boc-ΔAla-L-Ala-L-Hmb-L-App-NH2 

Relevant articles and documents

Efficient asymmetric synthesis of N-protected-β-aryloxyamino acids via regioselective ring opening of serine sulfamidate carboxylic acid

First regioselective ring opening of serine derived cyclic sulfamidate by hard nucleophiles like ArONa is developed, where β-elimination of serine sulfamidate ester by stronger nucleophiles is overcome by reversal of the electronic effect of the carboxyla

PHOSPHORORGANISCHE VERBINDUNGEN 109 DIE SYNTHESE FLUORESZIERENDER REAGENTIEN MIT CHEMOSELEKTIVEN ANKERGRUPPEN

A route for the synthesis of type B-compounds is reported.Compound 5 is a strong fluorescent and is O-selective.Type C-compounds, for example 10a to 10d show a high fluorescence and are O-selective.They are obtained via 6 and 7 (n = 2-4, 6; R = Me, X = F).Boc-serine is O-phosphonylated by the methyl-phophonicacid-esterfluorides, for example 10c. ω-(9-Acridinyl)alkyl-phosphonicacid-alkylesterfluorides, like 22, are available in only moderate yields via 15a-e as intermediates.More but unsuccesful experiments for the synthesis of fluorescent and O-selective acridine compounds are reported shortly.