451492-01-6

Basic information

• Product Name: ethyl 2-[(4-chlorophenyl)(tosylcarbamoyloxy)methyl]acrylate
• Synonyms: ethyl 2-[(4-chlorophenyl)(tosylcarbamoyloxy)methyl]acrylate
• CAS NO: 451492-01-6
• Molecular Weight: 437.901
• Mol File: 451492-01-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-[(4-chlorophenyl)(tosylcarbamoyloxy)methyl]acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(4-chlorophenyl)(tosylcarbamoyloxy)methyl]acrylate(451492-01-6)
• EPA Substance Registry System: ethyl 2-[(4-chlorophenyl)(tosylcarbamoyloxy)methyl]acrylate(451492-01-6)

Safety Data

• Hazardous Substances Data: 451492-01-6(Hazardous Substances Data)

Upstream product

• 4083-64-1 Tosyl isocyanate 
• 147849-98-7 ethyl 2-((4-chlorophenyl)(hydroxy)methyl)acrylate 

Downstream Products

• 451491-95-5 (E)-3-(4-Chloro-phenyl)-2-[(toluene-4-sulfonylamino)-methyl]-acrylic acid ethyl ester 

Relevant articles and documents

Diastereoselective functionalisation of Baylis-Hillman adducts: A convenient approach to α-methyl-α-amino acids

The N-tosyl carbamates 4a-e, easily prepared starting from the Baylis-Hillman adducts 3a-e, underwent cyclization carried out with I 2/NIS in the presence of NaH, to give the corresponding 2-oxo-1,3-oxazolidines 5a-e in good yield and total stereoselection when the substituent at C-5 is Ar. After the removal of tosyl group, followed by the cleavage of the heterocyclic ring, the α-methyl-α-amino acids 8a,b and 10 were obtained in good yield as hydrochlorides. Springer-Verlag 2010.