452092-34-1

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-(phenylmethoxy)-, ethyl ester
• CAS NO: 452092-34-1
• Molecular Formula: C22H19F2NO4
• Molecular Weight: 399.394
• Mol File: 452092-34-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-(phenylmethoxy)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-(phenylmethoxy)-, ethyl ester(452092-34-1)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-8-(phenylmethoxy)-, ethyl ester(452092-34-1)

Safety Data

• Hazardous Substances Data: 452092-34-1(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 926279-21-2 8-benzyloxy-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 

Downstream Products

• 452092-31-8 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic acid ethyl ester 

Relevant articles and documents

Novel Antibacterial Compounds

The invention relates to novel chimeric antibiotics of formula I wherein R1 is CH2NHCOR5, heteroarylmethyl, heteroaryloxymethyl or heteroarylaminomethyl;R2 is H, OH, OSO3H, OPO3H2, OCH2OPO3H2, OCOCH2CH2COOH, OCOR6;R3 is H or halogen;R4 is (C1-C3)alkyl, (C1-C3)haloalkyl or cycloalkyl;R5 is alkyl or haloalkyl; andR6 is the residue of a naturally occurring amino acid or of dimethylaminoglycine. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).

NOVEL ANTIBACTERIAL COMPOUNDS

The invention relates to novel chimeric antibiotics of formula (I) Wherein R1 is CH2NHCOR5, heteroarylmethyl, heteroaryloxymethyl or heteroarylaminomethyl; R2 is H, OH, OSO3H, OPO3H2, OCH2OPO3H2, OCOCH2CH2COOH, OCOR6; R3 is H or halogen; R4 is (C1-C3)alkyl, (C1-C3)haloalkyl or cycloalkyl; R5 is alkyl or haloalkyl; and R6 is the residue of a naturally occurring amino acid or of dimethylaminoglycine. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).