4524-77-0

Basic information

• Product Name: 2-bromo-4,6-dichlorophenol
• Synonyms: 2,4-Dichloro-6-bromophenol;6-Bromo-2,4-dichlorophenol
• CAS NO: 4524-77-0
• Molecular Formula: C₆H₃BrCl₂O
• Molecular Weight: 241.91
• EINECS: 224-855-6
• Mol File: 4524-77-0.mol
• Article Data: 20

Chemical Properties

• Melting Point: 67-69℃
• Boiling Point: 240℃
• Flash Point: 99℃
• Appearance: /
• Density: 1.890
• Vapor Pressure: 0.0258mmHg at 25°C
• Refractive Index: 1.5590 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-bromo-4,6-dichlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4,6-dichlorophenol(4524-77-0)
• EPA Substance Registry System: 2-bromo-4,6-dichlorophenol(4524-77-0)

Safety Data

• Hazardous Substances Data: 4524-77-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-4,6-dichlorophenol is a chemical compound with the molecular formula C6H3BrCl2O. It belongs to the family of organobromides and phenols, and appears as a white or slightly yellow crystalline powder or colourless to yellow needles. 2-bromo-4,6-dichlorophenol exhibits antimicrobial activity and is often used as an intermediate in the production of pharmaceuticals, pesticides, and dyestuffs. As with most chemicals, it should be handled with care due to potential toxicity and environmental concerns. Although its hazardousness to humans and animals isn't fully determined, its potential for causing eye and skin irritations along with its possible harmfulness if inhaled or swallowed warrants caution.

InChI:InChI=1/C6H3BrCl2O/c7-4-1-3(8)2-5(9)6(4)10/h1-2,10H

Upstream product

• 20244-58-0 2,4-dibromo-4,6-dichloro-cyclohexa-2,5-dienone 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 120-83-2 2,4-dichlorophenol 
• 7647-01-0 hydrogenchloride 
• 873983-87-0 4-bromo-2,6-dichloro-3-hydroxy-benzaldehyde 
• 108-95-2 phenol 
• 2446-83-5 di-isopropyl azodicarboxylate 
• 106-48-9 4-chloro-phenol 
• 860243-44-3 4-bromo-2-chloro-3-hydroxy-benzaldehyde 
• 56962-10-8 2-chloro-3-hydroxybenzaldehyde 
• 56962-14-2 2,6-dichloro-3-hydroxybenzaldehyde 
• 95-56-7 2-hydroxybromobenzene 

Downstream Products

• 60633-26-3 1-bromo-3,5-dichloro-2-methoxybenzene 
• 140163-69-5 3-(2-bromo-4,6-dichlorophenoxy)-1-propanol 
• 67044-77-3 <2-Brom-4,6-dichlor-phenoxy>-trimethylsilan 
• 609-89-2 2,4-dichloro-6-nitrophenol 
• 135062-15-6 N-<3-(2,4-dichloro-6-iodophenoxy)propyl>-N-methyl-2-propynylamine 
• 864642-82-0 1-bromo-3,5-dichloro-2-(2,2-difluoroethoxy)benzene 
• 1392073-00-5 1-(2,2,2-trifluoroacetylamino)cyclopropanecarboxylic acid (rac)-{5-[3,5-dichloro-2-(2,2-difluoroethoxy)phenyl]indan-1-yl}amide 
• 1022248-99-2 2-(2-bromo-4,6-dichlorophenoxy)-4-chloro-7-(1-ethylpropyl)-1-methyl-1H-benzimidazole 
• 1010390-52-9 C₉H₉BrCl₂O 
• 1010390-51-8 2-bromo-4,6-dichloroanethol 
• 1010390-54-1 C₈H₄BrCl₂F₃O 
• 1010390-53-0 C₉H₇BrCl₂F₂O 
• 67044-78-4 <2-Brom-4,6-dichlorphenoxy>-triphenylsilan 
• 871879-43-5 2-bromo-4,6-dichloro-3,5-dinitro-anisole 

Relevant articles and documents

-

-

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design

A series of novel allosteric antagonists of the GLP-1 receptor (GLP-1R), exemplified by HTL26119, are described. SBDD approaches were employed to identify HTL26119, exploiting structural understanding of the allosteric binding site of the closely related Glucagon receptor (GCGR) (Jazayeri et al., 2016) and the homology relationships between GCGR and GLP-1R. The region around residue C3476.36b of the GLP-1R receptor represents a key difference from GCGR and was targeted for selectivity for GLP-1R.

1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane: An efficient and high oxygen content oxidant in various oxidative reactions

Several oxidative approaches namely thiocyanation of aromatic compounds, epoxidation of alkenes, amidation of aromatic aldehydes, epoxidation of α β-unsaturated ketones, oxidation of sulfides to sulfoxides and sulfones, bayer-villeger reaction, bromination and iodation of aniline and phenol derivatives oxidative esterification, oxidation of pyridines and oxidation of secondary, allylic and benzyllic alcohols were carried out using 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as the potential solid oxidant which can be stored for several months without any loss in its activity. All of the procedures were accomplished via mild reaction conditions and the products were afforded in high yields and short reaction times.