452972-10-0 Usage
General Description
4-Chloro-3-pyridylboronic acid is a chemical compound with the molecular formula C5H5BClNO2. It is an organoboron compound that is commonly used in organic synthesis as a reagent for cross-coupling reactions. 4-CHLORO3-PYRIDYLBORONIC ACID is a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a ligand in the formation of transition metal complexes. 4-Chloro-3-pyridylboronic acid has a wide range of applications due to its ability to participate in various synthetic transformations, making it popular among chemists in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 452972-10-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,2,9,7 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 452972-10:
(8*4)+(7*5)+(6*2)+(5*9)+(4*7)+(3*2)+(2*1)+(1*0)=160
160 % 10 = 0
So 452972-10-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H5BClNO2/c7-5-1-2-8-3-4(5)6(9)10/h1-3,9-10H
452972-10-0Relevant articles and documents
Synthesis of novel halopyridinylboronic acids and esters. Part 2: 2,4, or 5-Halopyridin-3-yl-boronic acids and esters
Bouillon, Alexandre,Lancelot, Jean-Charles,Collot, Valerie,Bovy, Philippe R.,Rault, Sylvain
, p. 3323 - 3328 (2002)
This paper describes a general method for the synthesis and the isolation of novel 2,4, or 5-halopyridin-3-yl-boronic acids and esters 4, 7, 10, 13, 15. These compounds are prepared taking into account a regioselective halogen-metal exchange using nBuLi or a regioselective ortho-lithiation using lithium diisopropylamide and subsequent quenching with triisopropylborate starting from appropriate mono or dihalopyridines. All substrates studied to date provided a single regioisomeric boronic acid or ester product. Additionally, these compounds have been found to undergo Pb-catalyzed coupling with a range of arylhalides and authorize a strategy to produce new pyridines libraries.
