454-78-4Relevant articles and documents
Synthesis of racemic 1,2,3,4-tetrahydroisoquinolines and their resolution
Suna,Trapencieris
, p. 287 - 300 (2007/10/03)
1-Aniline-substituted 3,4-dihydroisoquinolines were obtained in various ways using the Bischler-Napieralski reaction. The effect of the protecting group at the aniline nitrogen atom on the course of the reaction has been studied and it was found that the N-phthalyl group was stable under the cyclization conditions. The dihydroisoquinolines were reduced to the racemic 1,2,3,4-tetrahydroisoquinolines which were resolved by crystallization of the diastereomeric tartrates. Two examples of 1,2,3, 4-tetrahydroisoquinolines were obtained in optically pure form (>99% ee).
REACTIONS OF ORGANIC COMPOUNDS WITH SF4-HF-HALOGENATING AGENT SYSTEMS VI. REACTIONS OF BENZENE AND ITS DERIVATIVES WITH SF4-HF-Cl2(Br2)
Kunshenko, B. V.,Omarov, V. O.,Muratov, N. N.,Mikhailevskii, S. M.,Yagupol'skii, L. M.
, p. 108 - 112 (2007/10/02)
In the reactions of benzene-carboxylic and -dicarboxylic acids with SF4-HF-Cl2(Br2), apart from the conversion of carboxyls into trifluoromethyl groups, there occurs the halogenation of the benzene ring with the formation of the corresponding chloro- and bromo-containing (trifluoromethyl)- and bis(trifluoromethyl)-benzenes.