454466-62-7

Basic information

• Product Name: 5-Hydroxybenzo[c]isoxazole
• Synonyms: 5-Hydroxybenzo[c]isoxazole;2,1-Benzisoxazol-5-ol;Benzo[c]isoxazol-5-ol
• CAS NO: 454466-62-7
• Molecular Formula: C₇H₅NO₂
• Molecular Weight: 135.122
• Mol File: 454466-62-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 307.506°C at 760 mmHg
• Flash Point: 139.775°C
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.664
• Storage Temp.: 2-8°C
• PKA: 8.44±0.40(Predicted)
• CAS DataBase Reference: 5-Hydroxybenzo[c]isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxybenzo[c]isoxazole(454466-62-7)
• EPA Substance Registry System: 5-Hydroxybenzo[c]isoxazole(454466-62-7)

Safety Data

• Hazardous Substances Data: 454466-62-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H5NO2/c9-6-1-2-7-5(3-6)4-10-8-7/h1-4,9H

Upstream product

• 454466-61-6 methyl 3-formyl-4-nitrophenyl carbonate 
• 454466-57-0 methyl 3-formylphenyl carbonate 
• 100-83-4 meta-hydroxybenzaldehyde 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 

Downstream Products

• 640293-17-0 2,1-benzisoxazole-4,5-dione 4-oxime 
• 831222-24-3 isoxazolo[3,4-e][2,1]benzisoxazole 

Relevant articles and documents

Gold(III)-catalyzed chemoselective annulations of anthranils with N-allylynamides for the synthesis of 3-azabicyclo[3.1.0]hexan-2-imines

We herein report the gold(iii)-catalyzed selective annulation of anthranils with N-allylynamides under mild conditions. By trapping the in situ-generated α-imino gold carbenes, 3-azabicyclo[3.1.0]hexan-2-imines were obtained in high synthetic efficiency. The reaction, which can be conducted in the gram scale, tolerates electron-rich and electron-deficient anthranils as well as a diverse set of functionalized ynamides (aryl- and alkyl-substituted terminal).

A novel cyclization to isoxazolo[3,4-e][2,1]benzisoxazole

Methylation of 2,1-benzisoxazole 4,5-dione 4-oxime 2 using dimethyl sulfate in DMF and in the presence of potassium carbonate gave a substantial yield of isoxazolo[3,4-e][2,1]benzisoxazole 4 by an unexpected cyclization reaction of the O-methylation product 3.