45515-23-9

Basic information

• Product Name: 4-METHYLOXAZOLE-5-METHANOL
• Synonyms: 4-METHYLOXAZOLE-5-METHANOL;4-Methyloxazole-5-methanol 97%;(4-Methyl-1,3-oxazol-5-yl)methanol;5-(Hydroxymethyl)-4-methyl-1,3-oxazole;4-Methyl-1,3-oxazole-5-methanol;4-Methyloxazole-5-Methanol, 97+%;(4-Methyloxazol-5-yl)Methanol;5-(Hydroxymethyl)-4-methyl-1,3-oxazole97%
• CAS NO: 45515-23-9
• Molecular Formula: C₅H₇NO₂
• Molecular Weight: 113.11
• Product Categories: Hydroxymethyl's;Oxazoles, Isoxazoles & Benzoxazoles;Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 45515-23-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 214.588°C at 760 mmHg
• Flash Point: 83.58°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 0.091mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-METHYLOXAZOLE-5-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLOXAZOLE-5-METHANOL(45515-23-9)
• EPA Substance Registry System: 4-METHYLOXAZOLE-5-METHANOL(45515-23-9)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 45515-23-9(Hazardous Substances Data)

Usage

General Description

4-Methyl-5-oxazolol is a chemical compound with the formula C4H5NO2. It is classified as an oxazole heterocyclic compound and is primarily used as a building block in organic synthesis and pharmaceutical research. The compound has also been reported to exhibit antimicrobial properties. As a 5-membered ring containing both nitrogen and oxygen, the oxazole ring system is a common structural motif in many natural products and pharmaceuticals. 4-Methyl-5-methanol-oxazole is a versatile and important chemical compound with various potential applications in the fields of medicine, agriculture, and materials science.

InChI:InChI=1/C5H7NO2/c1-4-5(2-7)8-3-6-4/h3,7H,2H2,1H3

Upstream product

• 23012-23-9 4-methyl-5-carbomethoxyoxazole 
• 16940-66-2 sodium tetrahydroborate 
• 20485-39-6 ethyl 4-methyloxazole-5-carboxylate 

Downstream Products

• 1312600-55-7 tert-butyl 4-{1-[(4-methyl-1,3-oxazol-5-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate 
• 45515-22-8 4-methyl-5-oxazolylmethyl chloride 
• 927911-45-3 5-((3-(6-bromo-1H-imidazo[4,5-b]pyridin-2-yl)-5-(2-fluorobenzyloxy)phenoxy)methyl)-4-methyloxazole 

Relevant articles and documents

HETEROCYCLIC GLP-1 AGONISTS

This disclosure relates to GLP-1 agonists of Formula (I), including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency

Non-covalent inhibitors of the main protease (Mpro) of SARS-CoV-2 having a pyridinone core were previously reported with IC50 values as low as 0.018 μM for inhibition of enzymatic activity and EC50 values as low as 0.8 μM for inhibition of viral replication in Vero E6 cells. The series has now been further advanced by consideration of placement of substituted five-membered-ring heterocycles in the S4 pocket of Mpro and N-methylation of a uracil ring. Free energy perturbation calculations provided guidance on the choice of the heterocycles, and protein crystallography confirmed the desired S4 placement. Here we report inhibitors with EC50 values as low as 0.080 μM, while remdesivir yields values of 0.5-2 μM in side-by-side testing with infectious SARS-CoV-2. A key factor in the improvement is enhanced cell permeability, as reflected in PAMPA measurements. Compounds 19 and 21 are particularly promising as potential therapies for COVID-19, featuring IC50 values of 0.044-0.061 μM, EC50 values of ca. 0.1 μM, good aqueous solubility, and no cytotoxicity.

3-(AZOLYLMETHOXY)BIPHENYL DERIVATIVES AS INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION

The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative diseases such as schizophrenia, Alzheimer, multiple sclerosis or Parkinson.