45515-45-5Relevant articles and documents
ORGANOMETALLIC COMPLEXES, ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME AND DISPLAY
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Paragraph 0122; 0123; 0132; 0133, (2020/03/17)
The present invention relates to an organic metal complex, an organic electroluminescence device using the same and a display device, and provided is an organic metal complex indicated as chemical formula 1 below. [Chemical Formula 1] Definition of the chemical formula 1 exists in the application.
Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment
Li, Xiaolin,Zhou, Kai,He, Haiying,Zhou, Qiong,Sun, Ya,Hou, Lijuan,Shen, Liang,Wang, Xiaofei,Zhou, Yuedong,Gong, Zhen,He, Shibo,Jin, Huangtao,Gu, Zhengxian,Zhao, Shuyong,Zhang, Long,Sun, Chunyan,Zheng, Shansong,Cheng, Zhe,Zhu, Yidong,Zhang, Minghui,Li, Jian,Chen, Shuhui
supporting information, p. 969 - 974 (2017/09/23)
The discovery of novel tetrahydropyrrolo[1,2-c]pyrimidines derivatives from Bay41-4109 as hepatitis B virus (HBV) inhibitors is herein reported. The structure-activity relationship optimization led to one highly efficacious compound 28a (IC50 = 10 nM) with good PK profiles and the favorite L/P ratio. The hydrodynamic injection model in mice clearly demonstrated the efficacy of 28a against HBV replication.
Physicochemical properties of imidazolium-derived ionic liquids with different C-2 substitutions
Liao, Chen,Shao, Nan,Han, Kee Sung,Sun, Xiao-Guang,Jiang, De-En,Hagaman, Edward W.,Dai, Sheng
experimental part, p. 21503 - 21510 (2012/03/10)
Five room temperature ionic liquids based on C-2 substituted imidazolium cations and bis(trifluoromethanesulfonyl)imide (TFSI) anions were synthesized and their physicochemical properties: thermal property, density, viscosity, ionic conductivity, self-diffusion coefficients, and electrochemical stability, were systematically investigated. The temperature dependence of both viscosity and ionic conductivities of these ionic liquids can be described by the Vogel-Fulcher-Tamman (VFT) equation. Compared with the reference, 1-propyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, the introduction of functional groups at the C-2 position generally increased the viscosity and lowered the ionic conductivity. The introduction of an ether group (-CH2OCH2CH2CH2CH3) at the C-2 position not only enhanced the reduction stability of the ionic liquids but also exhibited the lowest solid electrolyte interfacial resistance (R SEI). In contrast, the introduction of a cyano group (-CN) at the C-2 position not only decreased the reduction stability but also adversely increased the SEI resistance. The effect of the C-2 substitution on the reduction stability was explained by the change in the energy level of the lowest unoccupied molecular orbital. The self-diffusion coefficients (D) of each ion were measured by pulsed field gradient nuclear magnetic resonance (PFG-NMR). The lithium transference number (tLi) of 0.5 M LiTFSI/IL solutions calculated from the self-diffusion coefficients was in the range of 0.04 to 0.09.