45521-09-3

Basic information

• Product Name: D-THIAZOLIDINE-4-CARBOXYLIC ACID
• Synonyms: D-THIAPROLINE;D-THIAZOLIDINE-4-CARBOXYLIC ACID;D-THIOPROLINE;H-D-THZ-OH;d-4-thiazolidinecarboxylicaci;D-Hepalidine;(4S)-1,3-thiazolidine-4-carboxylic acid;(S)-4-Thiazolidinecarboxylic Acid
• CAS NO: 45521-09-3
• Molecular Formula: C₄H₇NO₂S
• Molecular Weight: 133.17
• EINECS: 256-240-3
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 45521-09-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 350.3 °C at 760 mmHg
• Flash Point: 165.7 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 7.63E-06mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: D-THIAZOLIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: D-THIAZOLIDINE-4-CARBOXYLIC ACID(45521-09-3)
• EPA Substance Registry System: D-THIAZOLIDINE-4-CARBOXYLIC ACID(45521-09-3)

Safety Data

• Hazardous Substances Data: 45521-09-3(Hazardous Substances Data)

Usage

Uses

D-THIAZOLIDINE-4-CARBOXYLIC ACID is a thiazolidine derivative with inhibitory effects on blood platelet aggregation. It is used in studies as a ligand for the catalytic asymmetric reduction of ketones with borane.

Definition

ChEBI: An optically active version of thioproline having D-configuration.

InChI:InChI=1/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m1/s1

Upstream product

• 34592-47-7 L-thioproline 
• 50-00-0 formaldehyd 
• 921-01-7 rac-cysteine 
• 444-27-9 (RS)-4-thiazolidinecarboxylic acid 
• 114192-98-2 (2R,3R)-2,3-Dihydroxy-succinic acid; compound with (S)-thiazolidine-4-carboxylic acid 
• 52-89-1 l-cysteine hydrochloride 
• 10318-18-0 DL-cysteine hydrochloride 
• 52-89-1 L-cysteine hydrochloride 
• 32443-99-5 D-cysteine hydrochloride 

Downstream Products

• 137441-54-4 C₃₁H₃₈N₂O₃S 
• 110822-04-3 N-(5-methyl-2-nitrobenzoyl)thiazolidine-4-carboxylic acid 
• 88381-44-6 N-nitrosothiazolidine-4-carboxylic acid 
• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 5025-82-1 N-acetyl-thiazolidine-4-carboxylic acid 
• 131570-70-2 (4aS,7aS,8R,8aR)-8-Phenyl-hexahydro-cyclopenta[4,5]pyrrolo[1,2-c]thiazol-7-one 
• 131570-71-3 (1S,6R,7R,11R)-11-Phenyl-4-thia-2-aza-tricyclo[5.3.1.0^2,6]undecan-8-one 
• 110822-07-6 N-(5-methyl-2-nitrobenzyl)thiazolidine-4-carboxylic acid 
• 51977-23-2 6-phenyl-1H,3H-imidazo<1,5-c>thiazole-5,7-<6H,7aH>-dione 
• 86634-64-2 Tetrahydro-6-phenyl-5-thioxoimidazo[1,5-c]thiazol-7(3H)-one 
• 86625-91-4 6-methyl-1H,3H-imidazo<1,5-c>thiazole<6H,7aH>-5-one-7-thione 
• 89860-79-7 N-(2-nitrophenyl)thiazolidine-4-carboxylic acid 
• 110271-24-4 N-(3,4-dichlorobenzoyl)thiazolidine-4-carboxylic acid 
• 110822-06-5 N-(2-nitrobenzyl)thiazolidine-4-carboxylic acid 

Relevant articles and documents

PROCESS FOR PURIFYING (METH)ACRYLIC ACID

A process for producing a grade of (meth)acrylic acid having residual formaldehyde levels of under 100 parts per million.

HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR INHIBITING LIPID ACCUMULATION CONTAINING SAME

The present invention relates to a novel heterocyclic carboxylic acid derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for inhibiting the accumulation of lipids in the body.

NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION

The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: (I) wherein Y is -S(O)m, -CH2-, CHF, or -CF2; m is 0, 1, or 2; X is a bond, C1-C5 alkyl (e.g., -CH2-), or -C(=0)-; the dotted line [----] in the carbocyclic ring represents an optional double bond; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl, CN, -COOR3, CONR3R4, -OR3, -NR3R4, or NR3COR3; R2 is hydrogen, cyano, COOH, or an isostere of a carboxylic acid (such as SO3H, CONOH, B(OH)2, PO3R3R4, SO2NR3R4, tetrazole, -COOR3, -CONR3R4, NR3COR4, or -COOCOR3).