455323-66-7

Basic information

• Product Name: Methyl 4-(4-piperidinyloxy)benzoate hydrochloride
• Synonyms: Methyl 4-(4-piperidinyloxy)benzoate hydrochloride;Methyl 4-(piperidin-4-yloxy)benzoate hydrochloride;Methyl 4-(piperidin-4-yloxy)benzoate, HCl;Methyl 4-(piperidin-4-yloxy)
• CAS NO: 455323-66-7
• Molecular Formula: C13H18ClNO3
• Molecular Weight: 271.73992
• Mol File: 455323-66-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 4-(4-piperidinyloxy)benzoate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(4-piperidinyloxy)benzoate hydrochloride(455323-66-7)
• EPA Substance Registry System: Methyl 4-(4-piperidinyloxy)benzoate hydrochloride(455323-66-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 455323-66-7(Hazardous Substances Data)

Usage

General Description

Methyl 4-(4-piperidinyloxy)benzoate hydrochloride, also known as Piperidinyloxybenzoate Methyl Hydrochloride, is a chemical compound with the formula C14H19NO3?HCl. This white to off-white crystalline substance is primarily utilized in the scientific research as an intermediate. As an intermediate, it's often used to facilitate the production of other compounds or chemicals, playing a critical role in pharmaceuticals, agrochemicals, dyestuffs, healthcare products, fragrances and other organic synthesis. Its exact impact, handling procedures, risk and safety measures depend on its specific concentration and usage in different contexts.

Upstream product

• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 281235-00-5 tert-butyl 4-(4-(methoxycarbonyl)phenoxy)piperidine-1-carboxylate 

Downstream Products

• 1595145-22-4 4-[(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]benzoic acid 

Relevant articles and documents

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: Structure-activity relationships, lead optimization, and chronic in vivo efficacy

Activation of the G-protein coupled receptor (GPCR) Takeda G-protein receptor 5 (TGR5), also known as G-protein bile acid receptor 1 (GPBAR1), has been shown to play a key role in pathways associated with diabetes, metabolic syndrome, and autoimmune disease. Nipecotamide 5 was identified as an attractive starting point after a high-throughput screen (HTS) for receptor agonists. A comprehensive hit-to-lead effort culminated in the discovery of 45h as a potent, selective, and bioavailable TGR5 agonist to test in preclinical metabolic disease models. In genetically obese mice (ob/ob), 45h was as effective as a dipeptidyl peptidase-4 (DPP-4) inhibitor at reducing peak glucose levels in an acute oral glucose tolerance test (OGTT), but this effect was lost upon chronic dosing.