4559-96-0

Basic information

• Product Name: 4'-BROMO-4-CHLOROBUTYROPHENONE
• Synonyms: P-BROMO-G-CHLOROBUTYROPHENONE;4'-BROMO-4-CHLOROBUTYROPHENONE 98%;4'-Bromo-4-chlorobutyrophenone,99%;4'-Bromo-γ-chlorobutyrophenone;γ-Chloro-4'-bromobutyrophenone;1-(4-BROMOPHENYL)-4-CHLORO-1-BUTANONE;1-(4-BROMOPHENYL)-4-CHLORO-1-OXOBUTANE;4-BROMO-GAMMA-CHLOROBUTYROPHENONE
• CAS NO: 4559-96-0
• Molecular Formula: C₁₀H₁₀BrClO
• Molecular Weight: 261.54
• EINECS: 224-930-3
• Mol File: 4559-96-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 35.5-38 °C(lit.)
• Boiling Point: 352.8°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.4780 (rough estimate)
• Refractive Index: 1.5963 (estimate)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 4'-BROMO-4-CHLOROBUTYROPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-4-CHLOROBUTYROPHENONE(4559-96-0)
• EPA Substance Registry System: 4'-BROMO-4-CHLOROBUTYROPHENONE(4559-96-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 4559-96-0(Hazardous Substances Data)

Usage

Chemical Properties

cream low melting powder

Uses

4'-Bromo-4-chlorobutyrophenone is used as a pharmaceutical & syntheses material intermediates.

Upstream product

• 589-87-7 1,4-bromoiodobenzene 
• 19936-14-2 1-(4-bromophenyl)cyclobutan-1-ol 
• 108-86-1 bromobenzene 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 112933-70-7 (S)-1-(4-Bromo-phenyl)-1-cyclopropyl-2-methanesulfinyl-ethanol 
• 130570-12-6 3-p-Methylphenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 130570-17-1 3-p-Methoxyphenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 130570-07-9 3-p-Fluorophenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 130570-02-4 3-p-Chlorophenyl-3-hydroxy-N-(4'-p-bromophenyl-4'-oxobutyl)quinuclidinium Chloride 
• 6952-89-2 (4-bromophenyl)(cyclopropyl)methanone 
• 84702-76-1 4-azido-4'-bromobutylphenone 
• 168907-66-2 4'-bromo-4-iodobutyrophenone 
• 43076-33-1 1-(4-bromophenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-one 
• 40133-22-0 2-(4-bromophenyl)thiophene 
• 40133-13-9 5-(4-bromo-phenyl)-thiophene-2-carboxylic acid 
• 38401-70-6 5-(p-Bromophenyl)thiophene-2-carboxaldehyde 
• 344417-31-8 2-Hydroxymethyl-5-(p-bromophenyl)thiophene 
• 62404-13-1 2-(4-bromo-phenyl)-5-chloromethyl-thiophene 

Relevant articles and documents

Preparation method of fexofenadine

The invention provides a preparation method of fexofenadine, which comprises the following steps: by using bromobenzene as a raw material, carrying out Friedel-Crafts acylation reaction to obtain 4'-bromo-4-chlorophenone ; enabling 4'-bromo-4-chlorobutanone and 1-methoxy-1-(trimethylsiloxy)-2-methyl-1-propene to subjected to coupling reaction to obtain 2-[4-(4 -chloro-1-butyryl)phenyl]-2-methyl methyl propionate; and sequentially carrying out N-alkylation, carbonyl reduction and alkaline hydrolysis on 2-[4-(4 -chloro-1-butyryl)phenyl]-2-methylpropanoate to obtain fexofenadine. The method has the advantages of cheap and easily available raw materials, easiness in operation, high yield, low cost, no meta-isomer, suitability for industrial production and the like.

A combined computational and experimental investigation of the oxidative ring-opening of cyclic ethers by oxoammonium cations

The propensity of oxoammonium cations to facilitate the oxidative ring-opening of cyclic ethers to their corresponding distal hydroxy ketones is investigated. The reaction has been evaluated using experimental and computational methods to gain deeper insight into trends in reactivity.

The synthesis of ω-(2-aryl-1,3-dioxolan-2-yl)alkyl purine derivatives and their activity towards HIV reverse transcriptase

Novel derivatives of 6-substituted purines were synthesized by alkylation of 6-substituted purines with various 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. Their inhibitory properties toward HIV reverse transcriptase were studied. The structure-activity relationship within the synthesized compounds was found.