457-77-2

Basic information

• Product Name: ethyl (4-fluorophenyl)carbamate
• Synonyms: carbamic acid, N-(4-fluorophenyl)-, ethyl ester
• CAS NO: 457-77-2
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.1796
• Mol File: 457-77-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 206.6°C at 760 mmHg
• Flash Point: 78.8°C
• Density: 1.224g/cm³
• Vapor Pressure: 0.235mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: ethyl (4-fluorophenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (4-fluorophenyl)carbamate(457-77-2)
• EPA Substance Registry System: ethyl (4-fluorophenyl)carbamate(457-77-2)

Safety Data

• Hazardous Substances Data: 457-77-2(Hazardous Substances Data)

Upstream product

• 101-99-5 N-carboethoxyaniline 
• 124-38-9 carbon dioxide 
• 75-03-6 ethyl iodide 
• 371-40-4 4-fluoroaniline 
• 64-17-5 ethanol 
• 1195-45-5 para-fluorophenyl isocyanate 
• 201230-82-2 carbon monoxide 
• 350-46-9 4-Fluoronitrobenzene 
• 404-47-7 (4-fluoro-phenyl)-thiocarbamic acid O-ethyl ester 
• 52162-36-4 C₉H₉F₂NO 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 153885-60-0 N-(4-fluorophenyl)hydrazinecarboxamide 
• 1356965-27-9 (5RS)-5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-N-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide 
• 1356965-19-9 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(4-fluorophenyl)hydrazinecarboxamide 
• 130409-77-7 2,4,6-trifluorophenylurethane 
• 145858-61-3 5-tert-Butyl-3-(4-fluoro-phenyl)-3H-oxazol-2-one 
• 2145-87-1 N-(2.4-Difluor-phenyl)-carbamidsaeureethylester 

Relevant articles and documents

Chemoselective synthesis of carbamates using CO2 as carbon source

Synthesis of carbamates directly from amines using CO2 as the carbon source is a straightforward and sustainable approach. Herein, we describe a highly effective and chemoselective methodology for the synthesis of carbamates at room temperature and atmosp

Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones

The synthesis and antibacterial activity of several new 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-ones 8 and analogous 2-(4-substituted phenyl)-3(2H)-isothiazolones 3 and 4 substituted at 4 and/or 3-positions of the phenyl moiety with different groups of which some have shown to increase the antibacterial activity of both 3-aryl-2-oxazolidinones and 3(2H)-isothiazolones is described. The most active compounds were isothiazolyl oxazolidinones 8a,j with unsubstituted and 8b with 4-F substituted phenyl rings which showed activities higher than analogous 3(2H)-isothiazolones and comparable or superior to linezolid, vancomycin, and ciprofloxacin against some tested microorganisms. The change in position of F and/or the use of larger substituents gave compounds with reduced or no activity. Evaluation of cytotoxicity to mouse fibroblast (NIH/3T3) cells indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations.

Synthesis of some heterocycle containing urea derivatives and their anti-viral activity

Some new isoindol heterocyclic ureas (6a-6i) have been synthesized using N-aminophthalimide (2) and ethyl N-monosubstituted/ethyl N,N-disubstituted carbamate (5a-5i). All the newly synthesized final compounds have been evaluated for their anti-viral activities against a variety of viruses. The compound (6f) with the methoxy substituent showed reasonably better activity as compared to the standard drugs against all the viruses (cf. Tables 1, 2 and 3). Further, all the products (6a-6i) were found to be active against Vesicular stomatitis virus, Coxsackie virus B4 and Respiratory syncytical virus (cf. Table 2) and the compounds (6h) and (6i) displayed better antiviral activity in comparison to Brivudin and (S)-DHPA (cf. Table 3).