457081-03-7

Basic information

• Product Name: JAK INHIBITOR I
• Synonyms: Merck-5;MERk-5;2-(tert-butyl)-9-fluoro-3H-benzo[h]iMidazo[4,5-f]isoquinolin-7(6H)-one;CMP 6;2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one;Merck-5 ,JAK INHIBITOR I;JAK Inhibitor;Pyridone 6
• CAS NO: 457081-03-7
• Molecular Formula: C18H16FN3O
• Molecular Weight: 309.34
• Product Categories: Inhibitors
• Mol File: 457081-03-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 646.481 °C at 760 mmHg
• Flash Point: 344.78 °C
• Appearance: /
• Density: 1.328
• Storage Temp.: -20C
• Solubility: Soluble in DMSO (30 mg/ml)
• PKA: 11.35±0.20(Predicted)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: JAK INHIBITOR I(CAS DataBase Reference)
• NIST Chemistry Reference: JAK INHIBITOR I(457081-03-7)
• EPA Substance Registry System: JAK INHIBITOR I(457081-03-7)

Safety Data

• Hazardous Substances Data: 457081-03-7(Hazardous Substances Data)

Usage

Description

Jak inhibitor I, also known as Pyridone 6, is a potent, ATP-competitive pan-JAK inhibitor with the chemical formula (457081-03-7). It effectively inhibits JAK 1, 2, and 3, as well as JAK family member Tyk2, with IC50 values of 1, 5, 15, and 1 nM, respectively. Pyridone 6 has also been tested against 21 other kinases, showing varying degrees of inhibition. Jak inhibitor I plays a significant role in inhibiting IL2 and IL4-dependent proliferation of CTLL cells, inducing intermediate mesoderm differentiation from embryonic stem cells, and suppressing allergic skin inflammation and asthmatic responses in mouse models.

Uses

Used in Pharmaceutical Industry:
Jak inhibitor I is used as a therapeutic agent for the treatment of myeloproliferative neoplasms and B cell acute lymphoblastic leukemia. Its potent inhibitory effects on JAK enzymes make it a promising candidate for clinical development in addressing these conditions.
Used in Immunology Research:
Jak inhibitor I serves as a valuable tool in immunology research, where it can be employed to study the role of JAK enzymes in immune cell signaling and the regulation of immune responses. This helps in understanding the underlying mechanisms of various immune-related diseases and the development of targeted therapies.
Used in Drug Discovery:
In the field of drug discovery, Jak inhibitor I is utilized as a lead compound for the development of novel JAK inhibitors with improved potency, selectivity, and pharmacological properties. This can lead to the discovery of new drugs with better efficacy and safety profiles for the treatment of various diseases, including autoimmune and inflammatory disorders.
Used in Preclinical Models:
Jak inhibitor I is used in preclinical models to evaluate its efficacy and safety in treating various diseases, particularly those involving JAK-STAT signaling pathways. This helps in assessing the potential of this compound as a therapeutic agent and provides valuable insights for further optimization and development.

References

Thompson et al. (2002) Photochemical preparation of a pyridine containing tetracycle: a JAK protein kinase inhibitor Med. Chem. Lett. 12 1219 Mae et al. (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells; Biochem. Biophys. Res. Commun. 393 877 Nakagawa et al. (2011) Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17; Immunol. 187 4611 Moriwaki et al. (2011) IL-13 suppresses double-stranded RNA-induced IFN-l production in lung cells; Biochem. Biophys. Res. Commun. 404 922