457654-72-7

Basic information

• Product Name: (R)-2-chlorophenylalanine methyl ester hydrochloride
• Synonyms: (R)-2-chlorophenylalanine methyl ester hydrochloride
• CAS NO: 457654-72-7
• Molecular Weight: 250.125
• Mol File: 457654-72-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-chlorophenylalanine methyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-chlorophenylalanine methyl ester hydrochloride(457654-72-7)
• EPA Substance Registry System: (R)-2-chlorophenylalanine methyl ester hydrochloride(457654-72-7)

Safety Data

• Hazardous Substances Data: 457654-72-7(Hazardous Substances Data)

Upstream product

• 1254365-74-6 C₁₅H₂₀ClNO₄ 
• 114873-02-8 (R)-2-((tert-butoxycarbonyl)amino)-3-(2-chlorophenyl)propanoic acid 
• 67-56-1 methanol 
• 80126-50-7 (R)-2'-chlorophenylalanine 

Downstream Products

• 1610691-89-8 (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester 
• 1610691-84-3 (R)-N-(2-chloroacetyl)-2-chlorophenylalanine methyl ester 

Relevant articles and documents

Rhodium-Catalyzed Enantioselective Synthesis of Oxazinones via an Asymmetric Ring Opening-Lactonization Cascade of Oxabicyclic Alkenes

The rhodium-catalyzed asymmetric ring opening reaction of oxabicyclic alkenes is shown to be an efficient method for synthesizing chiral heterocycles. We demonstrate that the pairwise combination of chiral catalyst with chiral amino-acid-derived pronucleophiles results in a stereodivergent synthesis of diastereomeric hydroxyesters. A favorable conformational preference induces the subsequent lactonization of one diastereomer leading to the highly enantioselective synthesis of oxazinones.