457889-95-1Relevant articles and documents
17S,20S-Methanofusidic acid, a new potent semi-synthetic fusidane antibiotic.
Duvold, Tore,Jorgensen, Anne,Andersen, Niels R,Henriksen, Anne S,Dahl Sorensen, Morten,Bjoerkling, Fredrik
, p. 3569 - 3572 (2002)
A novel fusidic acid type antibiotic having the side chain linked to the tetracyclic ring system via a spiro-cyclopropane system is described. 17S,20S-Methanofusidic acid is obtained by an efficient synthetic route including cyclopropanation of the Delta17(20) bond with attack solely from the least hindered alpha-face. The spiro-cyclopropane system orients the side chain into a bioactive conformational space. The new 17S,20S-methanofusidic acid exerts antibacterial activity against several Gram-positive species with potency essentially equal to natural fusidic acid.