459-40-5

Basic information

• Product Name: (2-fluoro-ethyl)-phenyl-amine
• Synonyms: (2-fluoro-ethyl)-phenyl-amine
• CAS NO: 459-40-5
• Molecular Weight: 139.173
• Mol File: 459-40-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (2-fluoro-ethyl)-phenyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-fluoro-ethyl)-phenyl-amine(459-40-5)
• EPA Substance Registry System: (2-fluoro-ethyl)-phenyl-amine(459-40-5)

Safety Data

• Hazardous Substances Data: 459-40-5(Hazardous Substances Data)

Usage

General Description

(2-fluoro-ethyl)-phenyl-amine, also known as 2-phenylethylamine or β-phenethylamine, is a chemical compound with the formula C8H11FN. It is a substituted phenethylamine, meaning it is a derivative of the natural neurotransmitter phenethylamine, which plays a role in the body's neurological and psychological functions. The addition of a fluorine atom and an ethyl group to the phenylamine molecule alters its properties and may impact its biological activity. (2-fluoro-ethyl)-phenyl-amine may have potential applications in medicinal chemistry and neuroscience research as a tool for investigating the structure-activity relationship of phenethylamine derivatives and their interactions with neurotransmitter systems in the body. However, it is important to note that the specific properties, uses, and potential risks of (2-fluoro-ethyl)-phenyl-amine would need to be further investigated and characterized through scientific studies and regulatory evaluations.

Upstream product

• 371-62-0 2-fluoroethanol 
• 62-53-3 aniline 
• 108-48-5 2,6-dimethylpyridine 
• 383-50-6 2-fluoroethyl tosylate 
• 54962-15-1 lithium N-ethyl-N-phenylamide 
• 5326-87-4 N-(phenyl)bromoacetamide 
• 330-68-7 2-fluoro-acetanilide 
• 108270-06-0 N-(benzyloxycarbonyl)-N-(2-fluoroethyl)aniline 
• 67-56-1 methanol 
• 762-49-2 2-fluoroethyl bromide 

Downstream Products

• 1246453-49-5 9-(2-fluoro-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide 
• 324-62-9 2-[N-(2-fluoro-ethyl)-anilino]-ethanol 

Relevant articles and documents

Method for preparing fluorine-containing secondary amine

The invention discloses a synthetic method of a fluorine-containing secondary amine compound. Pentamethylcyclopentadienyl iridium chloride dimer is used as a metal catalyst, fluoroalkyl comes from fluorinated alcohol, alkali is used as a co-catalyst, and the fluorine-containing secondary amine is prepared via the following step: primary amine reacts with the fluorinated alcohol under the action of the transition metal iridium catalyst and the alkali in an organic solvent to obtain the fluorine-containing secondary amine compound. The method overcomes the defects in the prior art that the fluorine-containing alkylating agent is high in toxicity and instable and needs to be prepared in advance, the reaction operation is complex, the steps are fussy and the like, and can obtain considerable yield. The adopted fluorinated alcohol is readily available, stable in chemical property and low in toxicity. The method is simple in reaction, has very high atom economy and step economy, and is energy-saving, environment-friendly and simple in operation. By adopting [Cp*IrCl2]2 as the catalyst, ligands are not needed, and the system is easy to realize.

Indole derivatives

An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor

IN VIVO IMAGING METHOD OF MOOD DISORDERS

The present invention provides a method useful in the diagnosis and/or monitoring of mood disorders wherein there is an abnormal expression of PBR. The method of the invention is useful in the differential diagnosis of said mood disorders and other condit