45966-51-6Relevant articles and documents
The Catalytic Asymmetric Intermolecular Prins Reaction
Diáz-Oviedo, C. David,Maji, Rajat,List, Benjamin
supporting information, p. 20598 - 20604 (2021/12/14)
Despite their significant potential, catalytic asymmetric reactions of olefins with formaldehyde are rare and metal-free approaches have not been previously disclosed. Here we describe an enantioselective intermolecular Prins reaction of styrenes and paraformaldehyde to form 1,3-dioxanes, using confined imino-imidodiphosphate (iIDP) Br?nsted acid catalysts. Isotope labeling experiments and computations suggest a concerted, highly asynchronous addition of an acid-activated formaldehyde oligomer to the olefin. The enantioenriched 1,3-dioxanes can be transformed into the corresponding optically active 1,3-diols, which are valuable synthetic building blocks.
Expanding the regioselective enzymatic repertoire: Oxidative mono-cleavage of dialkenes catalyzed by Trametes hirsuta
Paul, Caroline E.,Rajagopalan, Aashrita,Lavandera, Ivan,Gotor-Fernandez, Vicente,Kroutil, Wolfgang,Gotor, Vicente
supporting information; experimental part, p. 3303 - 3305 (2012/04/23)
The first report of a biocatalytic regioselective oxidative mono-cleavage of dialkenes was successfully achieved employing a cell-free enzyme preparation from Trametes hirsuta at the expense of molecular oxygen. Selected reactions were performed on a preparative scale affording high to excellent conversions and chemoselectivities. The Royal Society of Chemistry 2012.
