46001-36-9

Basic information

• Product Name: 8-Fluoro-2-Methyl-Quinoline
• Synonyms: 8-Fluoro-2-Methyl-Quinoline
• CAS NO: 46001-36-9
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.1756232
• Mol File: 46001-36-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Fluoro-2-Methyl-Quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Fluoro-2-Methyl-Quinoline(46001-36-9)
• EPA Substance Registry System: 8-Fluoro-2-Methyl-Quinoline(46001-36-9)

Safety Data

• Hazardous Substances Data: 46001-36-9(Hazardous Substances Data)

Usage

General Description

8-Fluoro-2-Methyl-Quinoline is a synthetic chemical compound belonging to the quinoline class of compounds known for their heterocyclic aromatic properties. The molecular formula for this chemical is C10H8FN with a molecular weight of 163.17 g/mol. It is characterized by a quinoline ring structure with a fluorine atom at the 8th position and a methyl group at the 2nd position. As with other quinoline compounds, 8-Fluoro-2-Methyl-Quinoline is often used in research and in the chemical industry. The properties and behavior of this compound are influenced by its specific molecular structure. However, detailed chemical, toxicological and ecological data regarding this compound might not be readily available, highlighting the importance of safe handling and proper disposal methods.

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 348-54-9 2-Fluoroaniline 
• 66023-21-0 2-methyl-6-(trifluoromethyl)-quinoline 
• 123-73-9 crotonaldehyde 

Downstream Products

• 914208-13-2 8-fluoroquinoline-2-carboxylic acid 
• 168083-16-7 3-(8-fluoro-2-quinolinylmethoxy)aniline 

Relevant articles and documents

Synthesis of palladium complexes with quinolino-based tridentate ligands and their applications for norbornene polymerization

Palladium complexes bearing new tridentate quinolino-based [N?NNox] ligands were synthesized and tested for the polymerization of norbornene. Upon activation of MAO, all the palladium complexes showed high catalytic activities for th

Discovery of an Inhibitor of the Proteasome Subunit Rpn11

The proteasome plays a crucial role in degradation of normal proteins that happen to be constitutively or inducibly unstable, and in this capacity it plays a regulatory role. Additionally, it degrades abnormal/damaged/mutant/misfolded proteins, which serves a quality-control function. Inhibitors of the proteasome have been validated in the treatment of multiple myeloma, with several FDA-approved therapeutics. Rpn11 is a Zn2+-dependent metalloisopeptidase that hydrolyzes ubiquitin from tagged proteins that are trafficked to the proteasome for degradation. A fragment-based drug discovery (FBDD) approach was utilized to identify fragments with activity against Rpn11. Screening of a library of metal-binding pharmacophores (MBPs) revealed that 8-thioquinoline (8TQ, IC50 value ～2.5 μM) displayed strong inhibition of Rpn11. Further synthetic elaboration of 8TQ yielded a small molecule compound (35, IC50 value ～400 nM) that is a potent and selective inhibitor of Rpn11 that blocks proliferation of tumor cells in culture.

COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION

Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed.