460086-11-7

Basic information

• Product Name: (S)-1-[(S)-2-(4-Phenyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-pyrrolidine-2-carboxylic acid amide
• Synonyms: (S)-1-[(S)-2-(4-Phenyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-pyrrolidine-2-carboxylic acid amide
• CAS NO: 460086-11-7
• Molecular Weight: 419.524
• Mol File: 460086-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-[(S)-2-(4-Phenyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-pyrrolidine-2-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[(S)-2-(4-Phenyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-pyrrolidine-2-carboxylic acid amide(460086-11-7)
• EPA Substance Registry System: (S)-1-[(S)-2-(4-Phenyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-pyrrolidine-2-carboxylic acid amide(460086-11-7)

Safety Data

• Hazardous Substances Data: 460086-11-7(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 88556-26-7 phenylbutyric acid N-hydroxysuccinimide ester 
• 35150-07-3 (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate 
• 7531-52-4 L-prolinamide 
• 124002-34-2 N-(4-Phenylbutyryl)-1,2,3,4-tetrahydroisoquinoline-3S-carboxylic acid 

Relevant articles and documents

Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases

Prolyl endopeptidases (PEPs) have been found in numerous species. Inhibitors of human enzyme could correct cognitive deficits in Alzheimer patients while inhibition of Trypanosoma cruzi PEP could prevent invasion phase in Chagas disease. A structure-activity relationship study carried out in a tetrahydroisoquinoline series allowed to obtain potent competitive inhibitors superior to SUAM-1221. Besides, inhibitors expected to act according to an irreversible mechanism revealed to be superior to JPT-4819, for applications linked to human enzyme inhibition.