461-81-4Relevant articles and documents
A novel synthesis of trifluoromethyl ethers via xanthates, utilizing BrF3
Ben-David, Iris,Rechavi, Dalit,Mishani, Eyal,Rozen, Shlomo
, p. 75 - 78 (1999)
Alcohols were transformed into trifluoromethyl ethers by converting them to xanthates in almost quantitative yields followed by a reaction with bromine trifluoride, a reagent rarely used in organic chemistry.
Direct Trifluoromethylation of Alcohols Using a Hypervalent Iodosulfoximine Reagent
Kalim, Jorna,Duhail, Thibaut,Pietrasiak, Ewa,Anselmi, Elsa,Magnier, Emmanuel,Togni, Antonio
supporting information, p. 2638 - 2642 (2021/01/21)
The direct trifluoromethylation of a variety of aliphatic alcohols using a hypervalent iodosulfoximine reagent afforded the corresponding ethers in moderate to good yields (14–72 %). Primary, secondary, and even tertiary alcohols, including examples derived from natural products, underwent this transformation in the presence of catalytic amounts of zinc bis(triflimide). Typical reaction conditions involved a neat mixture of 6.0 equivalents of the alcohol with 1.0 equivalent of the reagent, with the majority of reactions complete within 2 h with 2.5 mol % of the Lewis acid catalyst. Furthermore, experimental evidence was provided that the C?O bond-forming process occurred via the coordination of the alcohol to the iodine atom and subsequent reductive elimination.
DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME
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Page/Page column 43; 46; 56; 57-58, (2019/09/18)
The present invention provides a compound having the structure (I), a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.
