4619-74-3

Basic information

• Product Name: 2,4,6-TRIBROMO-3-METHYLPHENOL
• Synonyms: 2,4,6-TRIBROMO-3-CRESOL;2,4,6-TRIBROMO-3-METHYLPHENOL;2,4,6-tribromo-3-methyl-pheno;2,4,6-tribromo-m-creso;2,4,6-Tribromo-m-cresol;m-Cresol, 2,4,6-tribromo-;Micatex;Phenol, 2,4,6-tribromo-3-methyl-
• CAS NO: 4619-74-3
• Molecular Formula: C₇H₅Br₃O
• Molecular Weight: 344.83
• EINECS: 225-032-4
• Product Categories: Pharmaceutical Raw Materials;Aromatic Phenols;Organic Building Blocks;Oxygen Compounds;Phenols;Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 4619-74-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 81.5-85.5 °C(lit.)
• Boiling Point: 304.13°C (rough estimate)
• Flash Point: 123.8 °C
• Appearance: white solid
• Density: 2.2119 (rough estimate)
• Vapor Pressure: 0.00213mmHg at 25°C
• Refractive Index: 1.5580 (estimate)
• Storage Temp.: 2-8°C
• PKA: 6.46±0.28(Predicted)
• Merck: 14,9612
• BRN: 1949974
• CAS DataBase Reference: 2,4,6-TRIBROMO-3-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIBROMO-3-METHYLPHENOL(4619-74-3)
• EPA Substance Registry System: 2,4,6-TRIBROMO-3-METHYLPHENOL(4619-74-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: GP3500000
• Hazardous Substances Data: 4619-74-3(Hazardous Substances Data)

Usage

General Description

2,4,6-Tribromo-3-Methylphenol is a synthetic, organic chemical compound often utilized in various industries due to its unique properties. It is characterized by the presence of a phenol group, three bromine atoms and a methyl group attached to different positions in its benzene ring. 2,4,6-TRIBROMO-3-METHYLPHENOL displays reactivity typical for phenols, and the bromine substituents make it a good candidate for further reactions in organic synthesis. It is used in a wide array of applications including as an intermediate in the production of other chemicals, in research, and potentially in some antimicrobial applications. Given its chemical structure, it's essential to handle it with proper safety measures to prevent potential hazards.

InChI:InChI=1/C7H5Br3O/c1-3-4(8)2-5(9)7(11)6(3)10/h2,11H,1H3

Upstream product

• 41424-36-6 2,4,6-tribromo-3-methylanisole 
• 22356-80-5 2-hydroxy-4-methylbenzenesulfonic acid 
• 34946-83-3 2,4,4,6-tetrabromo-3-methyl-cyclohexa-2,5-dienone 
• 108-39-4 3-methyl-phenol 
• 100-63-0 phenylhydrazine 
• 7726-95-6 bromine 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 67-66-3 chloroform 
• 5532-72-9 2,4,6-tribromo-3-bromomethyl-phenol 
• 13321-76-1 2,4-dibromo-5-methylphenol 
• 7664-93-9 sulfuric acid 
• 5456-94-0 2,4-dibromo-5-methylanisole 
• 64-17-5 ethanol 

Downstream Products

• 58169-99-6 2,3,4,6-tetrabromo-5-methyl-phenol 
• 14401-03-7 2,6-dibromo-3-methyl-4-nitro-phenol 
• 859937-37-4 2,4-dibromo-3-methyl-6-nitro-phenol 
• 40100-94-5 2,6-dibromo-3-methylbenzoquinone 
• 55229-63-5 2-bromo-3-methyl-4,6-dinitro-phenol 
• 81574-59-6 2,4,6-trimethoxy-3-methylphenol 
• 129332-69-0 2,6-Dibromo-3-methyl-5-tridecyl-[1,4]benzoquinone 
• 129332-68-9 2,6-Dibromo-3-methyl-5-undecyl-[1,4]benzoquinone 
• 129332-67-8 3,5-dibromo-2-methyl-6-nonyl-1,4-benzoquinone 
• 129332-66-7 2,6-Dibromo-3-heptyl-5-methyl-[1,4]benzoquinone 
• 129332-65-6 2,6-Dibromo-3-methyl-5-pentyl-[1,4]benzoquinone 
• 77339-23-2 2,4,4,5,6-pentabromo-3-methylcyclohexa-2,5-dienone 
• 74204-00-5 3-bromo-5-methylphenol 
• 5532-72-9 2,4,6-tribromo-3-bromomethyl-phenol 

Relevant articles and documents

Preparation of carbazole and dibenzofuran derivatives by selective bromination on aromatic rings or benzylic groups with N-bromosuccinimide

N-Bromosuccinimide (NBS), a bromine source, has been used to study the bromination of toluidine and cresols systematically to clarify the underlying mechanism and the orientation effect. It has been found that bromination of toluidine and cresols which possess electron-donating NH2/OH with NBS gives electrophilic aromatic substitution products quickly instead of the desired benzylic bromination products. In contrast, when the electronic effect of the substituted groups is reversed, only the benzylic bromination products are gained. Based on this methodology, several potential AChE inhibitors, such as 2-methoxy-5-(benzylamino)methyl-dibenzofuran, 3-bromo-2-methoxy-5-methyl-9H- carbazole, 3,6-dibromo-2-methoxy-5-methyl-9H-carbazole, and 5-(bromomethyl)-2- methoxy-9H-(phenylsulfonyl)-carbazole have been synthesized.

The efficient and regioselective synthesis of the naphthoquinone core of streptovaricin U

The efficient and regioselective synthesis of the naphthoquinone core of streptovaricin U 1 via the Diels-Alder reaction of 1-methoxy-2-methyl-3-trimethylsilyloxybuta-1,3-diene 5 with the 2,6-dibromo-3-methyl-1,4-benzoquinone 6 is described.

Halogenation using quaternary ammonium polyhalides. XX. Bromination of phenols with polymer-bound benzyltrimethylammonium tribromide

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