462-51-1

Basic information

• Product Name: BIS(FLUOROMETHYL)ETHER
• Synonyms: BIS(FLUOROMETHYL)ETHER
• CAS NO: 462-51-1
• Molecular Formula: C₂H₄F₂O
• Molecular Weight: 82.05
• Mol File: 462-51-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: -70°C
• Boiling Point: 34°C
• Flash Point: -20°C
• Appearance: /
• Density: 1,208 g/cm3
• Vapor Pressure: 2360mmHg at 25°C
• Refractive Index: 1.27
• CAS DataBase Reference: BIS(FLUOROMETHYL)ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(FLUOROMETHYL)ETHER(462-51-1)
• EPA Substance Registry System: BIS(FLUOROMETHYL)ETHER(462-51-1)

Safety Data

• Hazard Codes: F
• Statements: 12
• Safety Statements: 3/7-9-16-29-33
• RIDADR: 3271
• Hazardous Substances Data: 462-51-1(Hazardous Substances Data)

Usage

General Description

BIS(FLUOROMETHYL)ETHER, also known as perfluoromethyl methyl ether, is a chemical compound with the formula C3F8O. It is a colorless, odorless, and nonflammable liquid that is commonly used as a solvent and refrigerant. BIS(FLUOROMETHYL)ETHER has a high dielectric constant, making it useful in electronics and as an insulating fluid in high-voltage equipment. It is also used as a propellant in aerosol products and as a heat transfer fluid in cooling systems. However, it is important to handle BIS(FLUOROMETHYL)ETHER with care as it can cause skin and eye irritation, and prolonged exposure may have adverse effects on human health.

InChI:InChI=1/C2H4F2O/c3-1-5-2-4/h1-2H2

Upstream product

• 50-00-0 formaldehyd 
• 353-50-4 Carbonyl fluoride 
• 67-68-5 dimethyl sulfoxide 
• 110-88-3 1,3,5-Trioxan 

Downstream Products

• 75-73-0 carbon tetrafluoride 
• 76-16-4 Hexafluoroethane 
• 2261-01-0 fluoromethyl trifluoromethyl ether 
• 1691-17-4 bis(difluoromethyl) ether 
• 461-63-2 difluoromethyl-fluoromethyl ether 
• 1479-49-8 bis(trifluoromethyl) ether 
• 3822-68-2 difluoromethyl trifluoromethyl ether 
• 28523-86-6 sevoflurane 

Relevant articles and documents

Carcinogen Chemistry. 4. (Haloalkyl)oxonium and (Haloalkyl)carboxonium Ions. Preparation, Nuclear Magnetic Resonance Structural Study, and Alkylating Ability

For exploration of the in vitro formation of the potential carcinogenic alkylating agents and particularly the reactive ionic intermediates derived from formaldehyde-hydrogen halides and haloalkyl ethers, their protolytic ionization under stable-ion conditions in low-nucleophilicity solutions was studied.The preparation, a NMR spectroscopic structural study, and the alkylating ability of a series of (haloalkyl)oxonium and (haloalkyl)carboxonium ions, including the previously elusive (fluoromethyl)- and (chloromethyl)oxonium ions, are reported, indicating their potential bioalkylating ability.

Process for Producing Fluoromethyl Hexafluoroisopropyl Ether

There is provided according to the present invention a process for producing fluoromethyl hexafluoroisopropyl ether ((CF3)2CH—O—CH2F), including: reacting bisfluoromethyl ether with hexafluoroisopropyl alcohol in a solvent substantially immiscible with hydrogen fluoride in the presence of a catalytic amount of a strong acid selected from sulfuric acid and any other acids stronger in acidity than sulfuric acid. The process of the present invention enables industrial production of the fluoromethyl hexafluoroisopropyl ether without using hydrogen fluoride or a large amount of sulfuric acid and thereby without causing a large amount of waste as a by-product.