46479-70-3

Basic information

• Product Name: 1,2,3,3A,8,8A-HEXAHYDRO-5-METHOXY-3A,8-DIMETHYL-PYRROLO[2,3-B]INDOLE
• Synonyms: 1,2,3,3A,8,8A-HEXAHYDRO-5-METHOXY-3A,8-DIMETHYL-PYRROLO[2,3-B]INDOLE
• CAS NO: 46479-70-3
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.298
• Mol File: 46479-70-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,3,3A,8,8A-HEXAHYDRO-5-METHOXY-3A,8-DIMETHYL-PYRROLO[2,3-B]INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,3A,8,8A-HEXAHYDRO-5-METHOXY-3A,8-DIMETHYL-PYRROLO[2,3-B]INDOLE(46479-70-3)
• EPA Substance Registry System: 1,2,3,3A,8,8A-HEXAHYDRO-5-METHOXY-3A,8-DIMETHYL-PYRROLO[2,3-B]INDOLE(46479-70-3)

Safety Data

• Hazardous Substances Data: 46479-70-3(Hazardous Substances Data)

Upstream product

• 109939-63-1 2-(2-(5-methoxy-1,3-dimethyl-2-oxoindolin-3-yl)ethyl)isoindoline-1,3-dione 
• 110691-50-4 1,3-dimethyl-3-(2-aminoethyl)-5-methoxyoxindole 
• 2291-51-2 (5-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetonitrile 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 13888-03-4 methyl 4-chloro-2-methylbutanoate 
• 940-11-4 N-methyl-N-nitroso-p-anisidine 
• 63483-09-0 4-chloro-2-methyl-butanal 
• 35292-54-7 N-methyl-N-(p-methoxyphenyl)hydrazine 

Downstream Products

• 2731-01-3 (±)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole 
• 114546-56-4 (-)-N¹-phenethylnoreseromethole 
• 57-47-6 (+/-)-Physostigmine 

Relevant articles and documents

Reduction of Oxindoles with Sodium Bis(2-methoxyethoxy)aluminum Hydride, A Novel Reducing Agent

1,3-Dimethyl-3-(2'-dimethylaminoethyl)-5-tetrahydropyranyloxyoxindole (5), obtained on C3-alkylation of oxindole (4), was reduced stereoselectively with sodium bis(2-methoxyethoxy)aluminum hydride (Vitride) to carbinolamine (6).Oxindoles (7, 8, 9, 10 and

A novel one-pot approach of hexahydropyrrolo[2,3-b ]indole nucleus by a cascade addition/cyclization strategy: Synthesis of (±)-esermethole

A practical and efficient synthesis of 3-substituted hexahydropyrrolo[2,3- b]indole is described. The addition/cyclization of 3-substituted indoles with α,β-dehydroamino esters in the presence of a Lewis acid provides hexahydropyrrolo[2,3-b]indole adducts in good yields and stereoselectivities. This approach has been applied to the concise synthesis of esermethole employing an appropriately substituted indole and an N-acyl dehydroamino ester.

Simple synthesis of racemic pyrrolo[2,3-b]indoles: Formal total synthesis of (±)-physostigmine

Racemic pyrrolo [2,3-b]indoles were efficiently synthesized by the reaction of aromatic hydrazines with 4-chloro-2-methylbutanal. A formal total synthesis of physostigmine was achieved.