465514-33-4

Basic information

• Product Name: (2-MORPHOLINOPHENYL)METHANOL
• Synonyms: BUTTPARK 98\12-70;(2-MORPHOLINOPHENYL)METHANOL;(2-MORPHOLIN-4-YL-PHENYL)METHANOL;RARECHEM AL BD 0462;(2-MORPHOLIN-4-YL-PHENYL)METHANOL 95%;2-(Morpholino-4-yl-phenyl)methanol;2-(4-Morpholinyl)benzenemethanol
• CAS NO: 465514-33-4
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• EINECS: 604-604-1
• Mol File: 465514-33-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 54 °C
• Boiling Point: 363℃
• Flash Point: 173℃
• Appearance: /
• Density: 1.160
• Vapor Pressure: 6.7E-06mmHg at 25°C
• Refractive Index: 1.568
• PKA: 14.26±0.10(Predicted)
• CAS DataBase Reference: (2-MORPHOLINOPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-MORPHOLINOPHENYL)METHANOL(465514-33-4)
• EPA Substance Registry System: (2-MORPHOLINOPHENYL)METHANOL(465514-33-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 465514-33-4(Hazardous Substances Data)

Usage

General Description

(2-Morpholinophenyl)methanol, also known as 2-Phenyl-2-hydroxymethyl morpholine, is a chemical compound with the molecular formula C10H15NO2. It is a white solid with a molecular weight of 181.23 g/mol. (2-MORPHOLINOPHENYL)METHANOL is often used as a building block in the synthesis of various pharmaceuticals and organic compounds. It contains a morpholine ring, which is a common structural feature in many bioactive molecules. Additionally, (2-Morpholinophenyl)methanol has been studied for its potential use as a chiral auxiliary in asymmetric synthesis processes due to its stereochemical properties. (2-MORPHOLINOPHENYL)METHANOL plays an important role in the development of new drugs and materials in the field of organic chemistry.

InChI:InChI=1/C11H15NO2/c13-9-10-3-1-2-4-11(10)12-5-7-14-8-6-12/h1-4,13H,5-9H2

Upstream product

• 394-35-4 methyl 2-fluorobenzoate 
• 58028-76-5 2-(morpholin-4-yl)benzaldehyde 
• 223560-37-0 methyl 2-morpholinobenzoate 

Downstream Products

• 110405-99-7 2-morpholinobenzyl chloride 
• 117323-28-1 4-[2-(1-Pyridin-2-yl-1H-imidazol-2-ylsulfanylmethyl)-phenyl]-morpholine 
• 117323-22-5 4-{2-[1-(3-Methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine 
• 117323-81-6 2-(2-Morpholin-4-yl-benzylsulfanyl)-1-pyridin-2-yl-1,4,5,6-tetrahydro-cyclopentaimidazole 
• 117323-27-0 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine 

Relevant articles and documents

An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect

Significant improvements in the synthesis of pyrido-fused heterocycles were observed when performing the reaction under solvent-free conditions, applying the tert-amino effect as the key ring closure methodology. An unexpected cyclization of ortho-(1′-aza

2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6- tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors

Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4,5-unsubstituted imidazole series 6-11 and the 1,4,5,6-tetrahydrocyclopent[d]imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+- ATPase. Structure-activity relationships indicate that the substitution of 2- pyridyl groups at the 1-position of the imidazole moiety combined with (2- aminobenzyl)sulfinyl groups at the 2-position leads to highly active compounds with a favorable chemical stability. Other substitution patterns in the imidazole moiety result in reducing biological activities. 2-[(2- Aminobenzyl)sulfinyl]-1-[2-(3-methylpyridyl)]-1,4,5,6- tetrahydrocyclopent[d]imidazole (12h, T-776) was selected for further development as a potential clinical candidate. Extensive study on the acid degradation of 12h indicates a mechanism of action different from that of omeprazole, the first H+/K+-ATPase inhibitor introduced to the market.