467-85-6 Usage
Originator
Normethadone, Isotec, Inc.
Manufacturing Process
65 g of thin powder sodium amide was added to a solution of 289 g diphenylacetonitrile in 300 ml benzene for 15-20 minutes at temperature 45°50°C. Then the mixture was cooled to about 25°C, 182 g 2dimethyaminoethylchloride was added dropwise. On ending the reaction it was heated to reflux for 15 minutes, diluted with water, the benzene layer separated and washed with diluted hydrochloric acid. The acid layer was alkalified with sodium hydroxide, extracted with ether and dried over potash. The ether was distilled off to dryness and the residue solidified to give colorless crystals of 4-dimethylamino-2,2-diphenylbutyronitrile. The C2H5MgBr was made from 66.5 g of magnesium, 300 ml dry ether and 33 g ethyl bromide and mixed with above prepared nitrile in 150 ml toluene. After the ending of reaction, the mixture was heated for 1.5 hour on the steam bath to give hard-grained bulk. It was mixed with 600 ml concentrate hydrochloric acid in 1500 ml water. On cooling 500 ml benzene was added and three layers arose. The middle layer crystallized shortly. The crystals were filtered off, washed with 100 ml 2 N hydrochloric acid and 3 x 100 ml acetone. 6Dimethylamino-4,4-diphenyl-3-hexanone was prepared as a hydrochloride. MP: 231°C. The salt may be transformed into the base by adding of an equivalent of any basic compound (triethyl amine, soda and so on).
Check Digit Verification of cas no
The CAS Registry Mumber 467-85-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 467-85:
(5*4)+(4*6)+(3*7)+(2*8)+(1*5)=86
86 % 10 = 6
So 467-85-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H25NO/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14H,4,15-16H2,1-3H3
467-85-6Relevant articles and documents
Easton,Nelson,Fish
, p. 5772 (1952)
Phenyl-substituted normethadones: Synthesis and pharmacology
Mbela,Poupaert,Cumps,Moussebois,Haemers,Borloo,Dumont
, p. 237 - 242 (2007/10/02)
Phenyl-substituted normethadone derivatives were synthesized and their affinity (IC50) for opioid receptors was determined by displacement of the specific binding sites of [3H]sufentanyl on rat brain preparations. Substitution resulted in a decrease of affinity in-vitro. These results suggest that normethadone-like compounds may interact with the P subsite of the μ-opioid receptor and that the P subsite has a well-defined cavity shape of stringent dimensions.
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