468071-50-3

Basic information

• Product Name: 2-Pyrrolidineacetic acid, 1-[(1S)-1-phenylethyl]-, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 468071-50-3
• Molecular Formula: C18H27NO2
• Molecular Weight: 289.418
• Mol File: 468071-50-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidineacetic acid, 1-[(1S)-1-phenylethyl]-, 1,1-dimethylethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidineacetic acid, 1-[(1S)-1-phenylethyl]-, 1,1-dimethylethyl ester, (2S)-(468071-50-3)
• EPA Substance Registry System: 2-Pyrrolidineacetic acid, 1-[(1S)-1-phenylethyl]-, 1,1-dimethylethyl ester, (2S)-(468071-50-3)

Safety Data

• Hazardous Substances Data: 468071-50-3(Hazardous Substances Data)

Upstream product

• 569679-82-9 (3R,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-pent-4-enoate 
• 164660-17-7 (3R,4E,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-hept-4-enoate 
• 81838-85-9 tert-butyl (2E,4E)-2,4-hexadienoate 
• 16809-92-0 tert-butyl (2E)-penta-2,4-dienoate 
• 115914-08-4 (S)-N-(1-phenylethyl)prop-2-en-1-amine 
• 468071-45-6 (2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate 

Downstream Products

• 104553-43-7 (2S,αS)-tert-butyl pyrrolidin-2-yl-acetate 
• 56633-75-1 (S)-2-(pyrrolidin-2-yl)acetic acid 

Relevant articles and documents

Asymmetric synthesis of cyclic β-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis

Diastereoselective conjugate addition of lithium (S)-N-allyl-N-α-methylbenzylamide to a range of α,β-unsaturated esters followed by ring closing metathesis is used to afford efficiently a range of substituted cyclic β-amino esters in high d.e. Alternatively, conjugate addition to α,β-unsaturated Weinreb amides, functional group conversion and ring closing metathesis affords cyclic amines in high d.e. The further application of this methodology to the synthesis of a range of carbocyclic β-amino esters via conjugate addition, enolate alkylation and ring closing metathesis is also described. Application of this methodology affords, after deprotection, (S)-homoproline, (S)-homopipecolic acid, (S)-coniine and (1S,2S)-trans-pentacin.