46817-91-8Relevant articles and documents
Lewis acid mediated intramolecular C-O bond formation of alkanol-epoxide leading to substituted morpholine and 1,4-oxazepane derivatives: Total synthesis of (±)-Viloxazine
Ghosh, Priya,Deka, Manash J.,Saikia, Anil K.
, p. 690 - 698 (2016/01/15)
Substituted morpholines have been efficiently synthesised in good yields from nitrogen tethered alkanol-epoxide mediated by boron trifluoride etherate. The methodology has been used for the total synthesis of (±)-viloxazine.
2-Aryloxymethylmorpholine histamine H3 antagonists
Letavic, Michael A.,Keith, John M.,Ly, Kiev S.,Bonaventure, Pascal,Feinstein, Mark A.,Lord, Brian,Miller, Kirsten L.,Motley, S. Timothy,Nepomuceno, Diane,Sutton, Steven W.,Carruthers, Nicholas I.
scheme or table, p. 5796 - 5799 (2009/11/30)
The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H3 antagonists is described. The new compounds are high affinity histamine H3 ligands that penetrate the CNS and occupy the histamine H3 receptor in rat brain.
2 Aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazines, a new class of antidepressants
Greenwood,Mallion,Todd,Turner
, p. 573 - 577 (2007/10/05)
Some 2 aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazines have been shown to possess marked antidepressant activity. The 1,4 oxazines were synthesized by lithium aluminium hydride reduction of the readily available 6 aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazin 3 ones. High antidepressant activity was associated with ortho substitution of the 2 phenoxymethyl group and with 1,4 oxazines devoid of 4 substituents.
