470-42-8

Basic information

• Product Name: marinobufagenin
• Synonyms: marinobufagenin;14,15β-Epoxy-3β,5-dihydroxy-5β-bufa-20,22-dienolide;3β,5-Dihydroxy-14,15β-epoxy-5β-bufa-20,22-dienolide;3β,5β-Dihydroxy-14β,15β-epoxybufa-20,22-dienolide;Marinobufagin;Marinobufogenin;(3β,5β,15β)-3,5-Dihydroxy-14,15-epoxybufa-20,22-dienolide
• CAS NO: 470-42-8
• Molecular Formula: C₂₄H₃₂O₅
• Molecular Weight: 400.50788
• Product Categories: Vasoconstrictor Agents;Enzyme Inhibitors
• Mol File: 470-42-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 224-225 °C
• Boiling Point: 589°Cat760mmHg
• Flash Point: 203°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• PKA: 14.77±0.70(Predicted)
• CAS DataBase Reference: marinobufagenin(CAS DataBase Reference)
• NIST Chemistry Reference: marinobufagenin(470-42-8)
• EPA Substance Registry System: marinobufagenin(470-42-8)

Safety Data

• Hazardous Substances Data: 470-42-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1

Upstream product

• 465-39-4 resibufogenin 

Downstream Products

• 472-26-4 5-((3S,5S,8R,9S,10R,13R,14S,17R)-3,5,14-Trihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pyran-2-one 
• 110414-67-0 Pentanedioic acid (3S,5S,8R,9S,10R,13R,14R,15R,17R)-5-hydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-hexadecahydro-20-oxa-cyclopropa[14,15]cyclopenta[a]phenanthren-3-yl ester 4-nitro-phenyl ester 
• 110390-78-8 Succinic acid (3S,5S,8R,9S,10R,13R,14R,15R,17R)-5-hydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-hexadecahydro-20-oxa-cyclopropa[14,15]cyclopenta[a]phenanthren-3-yl ester 4-nitro-phenyl ester 

Relevant articles and documents

New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus

Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu. The biotransformation of resibufogenin by Mucor polymorphosporus afforded 22 products, and 15 of them were new. The transformation reactions involved hydroxylations at C-1β, C-5, C-7α, C-7β, C-12α, C-12β and C-16α, as well as epimerization or dehydrogenation of 3-OH. Hydroxylations at C-12α, C-12β and C-16α were the major reactions, each giving products in >5% yields, whereas the other products were obtained in fairly low yields. Some of the products showed decreased but still potent cytotoxicities. This investigation provided a useful approach to prepare new bufadienolides and most of them were difficult to obtain by chemical means.