4729-06-0Relevant articles and documents
An efficient synthesis of (±)-cis-2-mino-6-hydroxy-9[4'-hydroxyethyl- 2'-cyclopenten-1'-yl]purine
Kim, Won,Kim, Hyangdug,Rhee, Hakjune
, p. 219 - 224 (2007/10/03)
The synthesis of a carbovir analogue, (±)-cis-2-amino-6-hydroxy-9- [4'hydroxyethyl-2'-cyclopenten-l'-yl]purine (2) was achieved from 2,5- norbornadiene (3) in six steps and 31% overall yield. This route involves a Meinwald rearrangement, one-pot operation (acid-hydrolysis and subsequent sodium borohydride reduction), and a Pd(0)catalyzed coupling reaction.