473693-79-7

Basic information

• Product Name: ETHYL 4-OXO-4-(3-THIENYL)BUTYRATE
• Synonyms: ETHYL 4-OXO-4-(3-THIENYL)BUTYRATE
• CAS NO: 473693-79-7
• Molecular Formula: C10H12O3S
• Molecular Weight: 212.27
• Mol File: 473693-79-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 330.5°C at 760 mmHg
• Flash Point: 153.7°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.000166mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: ETHYL 4-OXO-4-(3-THIENYL)BUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-OXO-4-(3-THIENYL)BUTYRATE(473693-79-7)
• EPA Substance Registry System: ETHYL 4-OXO-4-(3-THIENYL)BUTYRATE(473693-79-7)

Safety Data

• Hazardous Substances Data: 473693-79-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H12O3S/c1-2-13-10(12)4-3-9(11)8-5-6-14-7-8/h5-7H,2-4H2,1H3

Upstream product

• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 119405-65-1 tri-n-butyl(thien-3-yl)tin 

Relevant articles and documents

COUPLING OF ORGANOTIN REAGENTS WITH ARYL, ACYL AND HETEROARYL HALIDES: SYNTHESIS OF PYRIDAZINE AND QUINOXALONE DERIVATIVES

Couplin of organotin reagents Bu3SnAr (Ar = 2- or 3-thienyl, 2- or 3-pyridyl) with ClCOCH2CH2CO2Et in the presence of PdCl(CH2Ph)(PPh3)2 yields β-ketoesters ArCOCH2CH2CO2Et which were converted with hydrazine hydrate into 6-substituted 4,5-dihydropyridazin-3(2H)-ones, and thence to 3-halogeno-6-substituted pyridazines.The latter also couple under similar conditions with Bu3SnAr to yield 3-heteroarylpyridazines.With catalysts, coupling of ClCOCO2Et and Bu3SnAr proceeds with loss of carbon monoxide giving ArCO2Et, but without catalyst ArCOCO2Et is formed from which the3-heteroarylquinoxalin-3-one is prepared.The reactions of Bu3SnAr with 4-XC6H4Br (X = H,-OMe, -CN, -NO2) are also described.