473933-34-5Relevant articles and documents
Synthesis of new molecules containing head, spacer, and label moieties
Khatyr, Abderrahim,Maas, Huub,Calzaferri, Gion
, p. 6705 - 6710 (2002)
We describe the synthesis and characterization of novel molecules containing head with precise shape, spacer, and label moieties. The protocol is based on a Pd(0)-catalyzed cross-coupling reaction between ethynylphenyl/bromide to obtain a rigid head followed by the attachment of a flexible spacer possessing two reactive functional groups on the termini. The final step consists of forming a covalent bond between spacer and label. In addition, monosubstituted soluble labels were synthesized in good yields.