4750-57-6

Basic information

• Product Name: 1-METHYL-5-NITRO-1H-IMIDAZOLE-2-CARBALDEHYDE
• Synonyms: 1-METHYL-5-NITRO-1H-IMIDAZOLE-2-CARBALDEHYDE;1-METHYL-5-NITRO-1H-IMIDAZOLE-2-CARBALDEHYDE(WXG00257)
• CAS NO: 4750-57-6
• Molecular Formula: C₅H₅N₃O₃
• Molecular Weight: 155.1115
• EINECS: 225-270-9
• Mol File: 4750-57-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 368.8°Cat760mmHg
• Flash Point: 176.8°C
• Appearance: /
• Density: 1.52g/cm³
• Vapor Pressure: 1.24E-05mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-METHYL-5-NITRO-1H-IMIDAZOLE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-5-NITRO-1H-IMIDAZOLE-2-CARBALDEHYDE(4750-57-6)
• EPA Substance Registry System: 1-METHYL-5-NITRO-1H-IMIDAZOLE-2-CARBALDEHYDE(4750-57-6)

Safety Data

• Hazardous Substances Data: 4750-57-6(Hazardous Substances Data)

Usage

General Description

1-Methyl-5-nitro-1H-imidazole-2-carbaldehyde is a chemical compound with the molecular formula C5H5N3O3. It is a yellowish solid that is mainly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 1-METHYL-5-NITRO-1H-IMIDAZOLE-2-CARBALDEHYDE is widely used in organic chemistry as a building block for the preparation of various biologically active molecules. It is also known for its anti-inflammatory and antimicrobial properties, making it a valuable compound in the pharmaceutical industry. Additionally, it is used as a reagent in various chemical reactions, such as the synthesis of heterocyclic compounds and coordination complexes. Overall, 1-Methyl-5-nitro-1H-imidazole-2-carbaldehyde is an important chemical compound with a range of industrial and medical applications.

InChI:InChI=1/C5H5N3O3/c1-7-4(3-9)6-2-5(7)8(10)11/h2-3H,1H3

Upstream product

• 551-92-8 dimetridazole 
• 57434-36-3 5-nitro-1-methyl-2-(2-dimethylaminovinyl)-imidazole 
• 936-05-0 1-methyl-2-hydroxymethyl-5-nitroimidazole 
• 3034-38-6 5-nitro-1H-imidazole 

Downstream Products

• 31435-31-1 6-acetoxy-2-(1-methyl-5-nitro-1H-imidazol-2-ylmethylene)-benzofuran-3-one 
• 31435-32-2 6-hydroxy-2-(1-methyl-5-nitro-1H-imidazol-2-ylmethylene)-benzofuran-3-one 
• 129661-56-9 methyl-1 (isoxazolidinone-3 imino-4 methyl)-2 nitro-5 imidazole 
• 91017-58-2 Abunidazole 
• 936-05-0 1-methyl-2-hydroxymethyl-5-nitroimidazole 
• 74693-60-0 Acetic acid 1-ethyl-3-[(E)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)-vinyl]-2-oxo-1,2-dihydro-quinolin-4-yl ester 

Relevant articles and documents

Nitroimidazoles. IX. Synthesis of 2-acetyl-1-methyl-5-nitroimidazole

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Design, Synthesis, and Trypanocidal Activity of Novel 5-Nitroimidazolyl O-Benzyloxime Ethers

In this paper, we describe the synthesis and the action against of the trypomastigote form of Trypanosoma cruzi of a new class of nitroimidazole-2-carbaldehyde O-benzyloximes. These derivatives were designed through the application of molecular hybridization concept between two potent antiprotozoal compounds, the 5-nitrothiophene-2-carbaldehyde O-oxime 6 and the trypanocidal piperidinyl-4-carbaldehyde O-benzyloxime 7 with the intention of reaching two distinct molecular targets of T.?cruzi. The activity of these benzyl ether derivatives was tested against the infective trypomastigote forms of T.?cruzi, and the derivative (E)-1-methyl-5-nitro-1H-imidazole-2-carbaldehyde O-(4-nitrobenzyl) oxime (1) presented moderate trypanocidal activity (IC50?=?12.7?μM) when compared with the standard drug benznidazole, which showed to be a good starting point for the design of more effective trypanocide agents.

Compound and its as L-type calcium channel blocker or/and application of acetylcholine esterase inhibitors

Disclosed in this invention are compounds and the uses as L-type calcium channel blocker and/or acetylcholinesterase inhibitor thereof. The uses of said compounds in the manufactures of a medicament for the treatment of cardiovascular diseases, apoplexy or senile dementia are also disclosed in the present invention.

5-Nitroimidazole-based 1,3,4-Thiadiazoles: Heterocyclic analogs of metronidazole as anti-helicobacter pylori agents

A series of 5-nitroimidazole-based 1,3,4-thiadiazoles were prepared and tested for antibacterial activity against Helicobacter pylori. The anti-H. pylori activity of target compounds along with the commercially available antimicrobial metronidazole was evaluated by comparing the inhibition-zone diameters determined by the paper disc diffusion bioassay. From our bioassay results against 20 clinical isolates it is evident that piperazinyl, 4-methylpiperazinyl, 3-methylpiperazinyl, and 3,5-dimethylpiperazinyl analogs (6a, 6b, 6e, and 6f, respectively) and pyrrolidine derivative 7 had strong activity at 0.5 μg/disc (average of inhibition zone >20 mm) while metronidazole had no activity at this dose. Compound 6f containing the 3,5-dimethylpiperazinyl moiety at the 2-position of the 5-(1-methyl-5-nitro-1H- imidazol-2-yl)-1,3,4-thiadiazole skeleton was the most potent compound tested at low concentrations.