475058-41-4

Basic information

• Product Name: (S)-3-Hydroxypiperidine hydrochloride
• Synonyms: (S)-(-)-3-HYDROXYPIPERIDINE HYDROCHLORIDE;(S)-3-HYDROXYPIPERIDINE HYDROCHLORIDE;(S)-3-PIPERIDINOL HYDROCHLORIDE;(S)-PIPERIDIN-3-OL HYDROCHLORIDE;3-PIPERIDINOL, HYDROCHLORIDE, (3S)-;S-3-HYDROXY PIPERIDINE HCL;(3S)-(-)-3-Hydroxypiperidine hydrochloride;3-Piperidinol, hydrochloride (1:1), (3S)-
• CAS NO: 475058-41-4
• Molecular Formula: C₅H₁₁NO*ClH
• Molecular Weight: 137.61
• Product Categories: pharmacetical;Piperidines
• Mol File: 475058-41-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 185-188°C
• Boiling Point: 231.6 °C at 760 mmHg
• Flash Point: 93.8 °C
• Appearance: /
• Vapor Pressure: 0.0117mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Soluble in water
• CAS DataBase Reference: (S)-3-Hydroxypiperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Hydroxypiperidine hydrochloride(475058-41-4)
• EPA Substance Registry System: (S)-3-Hydroxypiperidine hydrochloride(475058-41-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 475058-41-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

S)-3-Hydroxypiperidine Hydrochloride acts as a reagent in the synthetic preparation of benzothiazole and benzoxazole derivatives as H3 receptor ligands for treating diseases.

InChI:InChI=1/C5H11NO.ClH/c7-5-2-1-3-6-4-5;/h5-7H,1-4H2;1H/t5-;/m0./s1

Upstream product

• 924651-55-8 tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate 
• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 
• 924651-52-5 allyl-(2-methoxymethoxy-but-3-enyl)-carbamic acid tert-butyl ester 
• 924651-53-6 3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 886450-69-7 (4-fluoro-phenyl)-((S)-3-hydroxy-piperidin-1-yl)-methanone 
• 1247085-74-0 3-fluoro-4-(3-hydroxypiperidin-1-yl)benzonitrile 
• 1089282-16-5 (3S)-1-[3-(methyloxy)-4-nitrophenyl]-3-piperidinol 
• 1246289-50-8 C₁₇H₁₈Cl₂N₂O 
• 62367-59-3 (S)-3-hydroxy-1-methylpiperidine 
• 1039511-72-2 5-chloro-N-((1-(2-((S)-3-hydroxypiperidin-1-yl)-4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide 
• 916988-48-2 1-(2-fluoro-4-nitrophenyl)-piperidin-3-ol 
• 1495327-05-3 3,5-difluoro-4-(3-hydroxypiperidin-1-yl)benzonitrile 
• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 

Relevant articles and documents

Method for industrially producing (S)-3-(4-bromophenyl) piperidine

The invention belongs to the field of chemical medicine synthesis, and provides a method for industrially producing (S)-3-(4-bromophenyl) piperidine. The method comprises the following steps: by taking (S)-1-tert-butyloxycarbonyl-3-hydroxypiperidine as an initial raw material, removing tert-butyloxycarbonyl protecting groups to obtain (S)-3-hydroxypiperidine hydrochloride A; condensing the intermediate A and thionyl chloride to generate a five-membered ring sulfinate intermediate B; oxidizing the intermediate B to generate a five-membered ring sulfonate C; carrying out nucleophilic substitution reaction on the compound C and aryl anions, and meanwhile, carrying out configuration inversion to generate the target product (S)-3-(4-bromophenyl) piperidine. According to the whole process, high-pressure hydrogenation, diazotization and other operations are not used, and no chiral resolution reagent is used, so that the total cost is lower, the operation is simple and convenient, higher chiral purity can be maintained, and the method is suitable for industrial large-scale production.