475160-89-5

Basic information

• Product Name: Carbamic acid, [[4-(hydroxymethyl)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester
• CAS NO: 475160-89-5
• Molecular Formula: C23H21NO3
• Molecular Weight: 359.425
• Mol File: 475160-89-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [[4-(hydroxymethyl)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [[4-(hydroxymethyl)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester(475160-89-5)
• EPA Substance Registry System: Carbamic acid, [[4-(hydroxymethyl)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester(475160-89-5)

Safety Data

• Hazardous Substances Data: 475160-89-5(Hazardous Substances Data)

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 56-91-7 p-aminomethylbenzoic acid 
• 164470-64-8 N-(9-fluorenylmethyloxycarbonyl)-4-(aminomethyl)benzoic acid 

Downstream Products

• 475160-90-8 (4-formylbenzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Dioxanes and uses thereof

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2, R3, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.

Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin.

Seventy-two hundred potential inhibitors of the histone deacetylase (HDAC) enzyme family, based on a 1,3-dioxane diversity structure, were synthesized on polystyrene macrobeads. The compounds were arrayed for biological assays in a "one bead-one stock sol