475221-20-6 Usage
Uses
Nogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) modelto determine the effects of Nogo-A/NgR1 on autophagic activationto study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice
Biochem/physiol Actions
Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 475221-20-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,5,2,2 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 475221-20:
(8*4)+(7*7)+(6*5)+(5*2)+(4*2)+(3*1)+(2*2)+(1*0)=136
136 % 10 = 6
So 475221-20-6 is a valid CAS Registry Number.
