4753-03-1

Basic information

• Product Name: 2'-iodo-2'-deoxyuridine
• Synonyms: 2'-iodo-2'-deoxyuridine;2'-Deoxy-2'-iodouridine
• CAS NO: 4753-03-1
• Molecular Formula: C₉H₁₁IN₂O₅
• Molecular Weight: 354.1
• Mol File: 4753-03-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 2.13g/cm³
• CAS DataBase Reference: 2'-iodo-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-iodo-2'-deoxyuridine(4753-03-1)
• EPA Substance Registry System: 2'-iodo-2'-deoxyuridine(4753-03-1)

Safety Data

• Hazardous Substances Data: 4753-03-1(Hazardous Substances Data)

Upstream product

• 3736-77-4 2,2'-Anhydrouridine 

Downstream Products

• 321155-82-2 1-[5-O-(4-methoxytrityl)-2-deoxy-2-iodo-3-O-(dimethylvinylsilyl)-β-D-ribofuranosyl]uracil 
• 321155-88-8 1-[5-O-(4-methoxytrityl)-2-deoxy-2-vinyl-3-O-(tert-butyldimethylsilyl)-β-D-ribo-pentofuranosyl]cytosine 
• 321155-87-7 1-[5-O-(4-methoxytrityl)-2-deoxy-2-vinyl-3-O-(tert-butyldimethylsilyl)-β-D-ribo-pentofuranosyl]uracil 
• 321155-92-4 1-[5-O-(4-methoxytrityl)-2-deoxy-2-iodo-3-O-(diphenylvinylsilyl)-β-D-ribofuranosyl]uracil 
• 184296-88-6 Thiocarbonic acid O-[(2R,3R,4R,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-iodo-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 321155-80-0 1-[5-O-(4-methoxytrityl)-2-deoxy-2-iodo-β-D-ribofuranosyl]uracil 
• 3736-77-4 2,2'-Anhydrouridine 
• 78508-96-0 (5S)-5-(hydroxymethyl)-5H-furan-2-one 
• 34371-14-7 2-deoxy-D-ribonolactone 

Relevant articles and documents

2′-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible approach to the synthesis of double spin-labeled DNA duplexes, where 2′-alkynylnucleosides are incorporated at terminal and internal positions on complementary strands. Post-DNA synthesis copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with a variety of spin labels enable the use of double electron-electron resonance experiments to measure a number of distances on the duplex, affording a high level of detailed structural information.

Nucleic acid related compounds. 91. Biomimetic reactions are in harmony with loss of 2'-substituents as free radicals (not anions) during mechanism-based inactivation of ribonucleotide reductases. Differential interactions of azide, halogen, and alkylthio

The initial step in the mechanism-based inactivation of ribonucleotide reductases by 2'-chloro-2'deoxynucleotides is abstraction of H3' by a proximal free radical on the enzyme. The C3' radical is postulated to undergo spontaneous loss of chloride, and th