4753-75-7

Basic information

• Product Name: N-METHYLFURFURYLAMINE
• Synonyms: N-METHYLFURFURYLAMINE;n-methyl-2-furanmethanamin;N-furfuryl-N-methylamine;(2-furylmethyl)methylamine hydrochloride;1-(2-furyl)-N-methylmethanamine;2-Furanmethanamine, N-methyl-;Inchi=1/C6H9no/C1-7-5-6-3-2-4-8-6/H2-4,7H,5H2,1h;(2-furylmethyl)methylamine(SALTDATA: FREE)
• CAS NO: 4753-75-7
• Molecular Formula: C₆H₉NO
• Molecular Weight: 111.14
• EINECS: 225-278-2
• Product Categories: Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 4753-75-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 148-152 °C(lit.)
• Flash Point: 105 °F
• Appearance: /
• Density: 0.982 g/mL at 25 °C(lit.)
• Vapor Pressure: 4.11mmHg at 25°C
• Refractive Index: n20/D 1.471(lit.)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.96±0.10(Predicted)
• CAS DataBase Reference: N-METHYLFURFURYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLFURFURYLAMINE(4753-75-7)
• EPA Substance Registry System: N-METHYLFURFURYLAMINE(4753-75-7)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 4753-75-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow. Refr index1.4700–1.4720 (25C), distilling range 144–153C.Combustible.

Uses

Different sources of media describe the Uses of 4753-75-7 differently. You can refer to the following data:
1. Intermediate.
2. N-Methylfurfurylamine may be used in the synthesis of cis -α-[2-[(2-furanylmet hyl)methylamino]cyclohexyl]-benzenemethanol.

General Description

N-Methylfurfurylamine is a secondary amine. It can be prepared by reacting furfural and aqueous trimethylamine.

InChI:InChI=1/C6H9NO/c1-7-5-6-3-2-4-8-6/h2-4,7H,5H2,1H3/p+1

Upstream product

• 98-01-1 furfural 
• 4437-18-7 2-bromomethylfuran 
• 39558-97-9 N-methylfurfurylidenamine 
• 617-89-0 furan-2-ylmethanamine 
• 593-51-1 methylamine hydrochloride 
• 333-27-7 methyl trifluoromethanesulfonate 
• 21402-85-7 N-methylfuran-2-carboxamide 

Downstream Products

• 107428-53-5 1-phenyl-2-(furfurylmethylamino)ethanol 
• 1185190-08-2 4-(3,5-dimethylphenylsulfanyl)-5-[N-(furan-2-ylmethyl)-N-methyl]aminomethyl-3-iodo-6-methyl-pyridin-2(1H)-one 
• 1185189-02-9 4-(3,5-dimethylphenoxy)-5-[N-(furan-2-ylmethyl)-N-methyl]aminomethyl-3-iodo-6-methyl-pyridin-2(1H)-one 
• 1255652-73-3 2-(2-((tert-butoxycarbonyl)(4-cyclohexylbenzyl)amino)-6-((furan-2-ylmethyl)(methyl)amino)-9H-purin-9-yl)acetic acid 
• 1255653-13-4 2-(2-((4-cyclohexylbenzyl)amino)-6-((furan-2-ylmethyl)(methyl)amino)-9H-purin-9-yl)acetic acid 
• 1255652-38-0 ethyl 2-(2-((tert-butoxycarbonyl)(4-cyclohexylbenzyl)amino)-6-((furan-2-ylmethyl)(methyl)amino)-9H-purin-9-yl)acetate 
• 1612763-53-7 N-(furan-2-ylmethyl)-N-methyl-4-[(1,1,3-trioxo-2,3-dihydro-1λ⁶,2-benzothiazol-2-yl)methyl]benzamide 

Relevant articles and documents

Synthesis of trans-2-Substituted Cyclopropylamines from α-Chloroaldehydes

Cyclopropylamines are prevalent in pharmaceuticals and agrochemicals. Herein, we report the synthesis of trans-2-substituted cyclopropylamines in high diastereoselectivity from readily available α-chloroaldehydes. The reaction proceeds via trapping of an electrophilic zinc homoenolate with an amine followed by ring closure to generate the cyclopropylamine. We have also observed that cyclopropylamine cis/trans-isomerization occurs in the presence of zinc halide salts and that this process can be turned off by the addition of a polar aprotic cosolvent.

Amidation of unactivated ester derivatives mediated by trifluoroethanol

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

Selective monomethylation of primary amines with simple electrophiles

Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%). The key point of this single methyl transfer stems from the use of HFIP as the solvent that interferes with amines and avoids overmethylation.