4761-26-6Relevant articles and documents
Zeolite mediated Michael addition of 1,3-dicarbonyl compounds and thiols
Sreekumar,Rugmini,Padmakumar, Raghavakaimal
, p. 6557 - 6560 (1997)
Zeolites, an environmentally attractive solid catalyst, proves to be an efficient catalyst for Michael addition of several 1,3-dicarbonyl compounds and thiols as donors with methyl vinyl ketone, acrolein and methyl acrylate as acceptors without any solvent are described.
Metal-dioxidoterephthalate MOFs of the MOF-74 type: Microporous basic catalysts with well-defined active sites
Valvekens, Pieterjan,Vandichel, Matthias,Waroquier, Michel,Van Speybroeck, Veronique,De Vos, Dirk
, p. 1 - 10 (2014/07/21)
The hybrid frameworks M2dobdc (dobdc4- = 2,5-dioxidoterephthalate, M2+ = Mg2+, Co2+, Ni2+, Cu2+ and Zn2+), commonly known as CPO-27 or MOF-74, are shown to be active catalysts in base-catalyzed reactions such as Knoevenagel condensations or Michael additions. Rather than utilizing N-functionalized linkers as a source of basicity, the intrinsic basicity of these materials arises from the presence of the phenolate oxygen atoms coordinated to the metal ions. The overall activity is due to a complex interplay of the basic properties of these structural phenolates and the reactant binding characteristics of the coordinatively unsaturated sites. The nature of the active site and the order of activity between the different M 2dobdc materials were rationalized via computational efforts; the most active material, both in theory and in experiment, is the Ni-containing variant. The basicity of Ni2dobdc was experimentally proven by chemisorption of pyrrole and observation by IR spectroscopy.
Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes
Chandan, Nandkishor,Thompson, Amber L.,Moloney, Mark G.
supporting information, p. 7863 - 7868 (2013/07/05)
Substituted pyrrolines are available by ring closure initiated by direct nucleophilic attack of stabilized enolates at the nitrogen of oximes activated with a leaving group, in a process which effectively out-competes the more usual Beckmann rearrangement. Subsequent reduction provides diastereoselective access to the corresponding pyrrolidines. This provides a rapid route to saturated heterocyclic systems from readily available precursors.
