477202-00-9
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Basic information
- Product Name: ipilimumab
- Synonyms: ipilimumab
- CAS NO:477202-00-9
- Molecular Formula:
- Molecular Weight:
- EINECS: N/A
- Product Categories: N/A
- Mol File: 477202-00-9.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: ipilimumab(CAS DataBase Reference)
- NIST Chemistry Reference: ipilimumab(477202-00-9)
- EPA Substance Registry System: ipilimumab(477202-00-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 477202-00-9(Hazardous Substances Data)
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477202-00-9 Usage
Description
Ipilimumab is a CTLA-4 blocking antibody that was approved by the U.S. FDA in March 2011 for the treatment of unresectable or metastatic melanoma. Therefore, ipilimumab has an indirect effect on tumors that is mediated through blockade of CTLA-4 negative signaling and augmentation of T-cell activity. It is one of a handful of immunostimulatory drugs (e.g., aldesleukin and interferon alfa-2b) now approved for cancer therapy.Uses
Treatment of oncology disease and HIV infection.Brand name
YervoyClinical Use
Antineoplastic agent: Treatment of advanced (unresectable or metastatic) melanoma in adults who have received prior therapyMetabolism
Most likely removed by opsonisation via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.Check Digit Verification of cas no
The CAS Registry Mumber 477202-00-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,7,2,0 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.Calculate Digit Verification of CAS Registry Number 477202-00:
(8*4)+(7*7)+(6*7)+(5*2)+(4*0)+(3*2)+(2*0)+(1*0)=139
139 % 10 = 9
So 477202-00-9 is a valid CAS Registry Number.
477202-00-9Upstream product
477202-00-9Downstream Products
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ipilimumab
