478157-01-6

Basic information

• Product Name: methyl 2-diazo-2-(2-((4-methoxybenzyl)oxy)phenyl)acetate
• Synonyms: methyl 2-diazo-2-(2-((4-methoxybenzyl)oxy)phenyl)acetate
• CAS NO: 478157-01-6
• Molecular Weight: 312.325
• Mol File: 478157-01-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-diazo-2-(2-((4-methoxybenzyl)oxy)phenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-diazo-2-(2-((4-methoxybenzyl)oxy)phenyl)acetate(478157-01-6)
• EPA Substance Registry System: methyl 2-diazo-2-(2-((4-methoxybenzyl)oxy)phenyl)acetate(478157-01-6)

Safety Data

• Hazardous Substances Data: 478157-01-6(Hazardous Substances Data)

Upstream product

• 22446-37-3 methyl (2-hydroxyphenyl)acetate 
• 614-75-5 2-Hydroxyphenylacetic acid 

Downstream Products

• 3923-14-6 methyl 2-(4-methoxyphenyl)benzo[b]furan-3-carboxylate 

Relevant articles and documents

Metal-Free Tandem Rearrangement/Lactonization: Access to 3,3-Disubstituted Benzofuran-2-(3H)-ones

A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(3H)-ones through reacting α-aryl-α-diazoacetates with triarylboranes is presented. Initially, triarylboranes were successfully investigated in α-arylations of α-diazoacetates, however in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes an intramolecular rearrangement to form a quaternary center. The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuranones in good yields.