4783-83-9

Basic information

• Product Name: 4-(P-NITROPHENOXY)-PYRIDINE
• Synonyms: 4-(P-NITROPHENOXY)-PYRIDINE;PYRIDINE, 4-(4-NITROPHENOXY)-;4-(4-nitrophenoxy)pyridine
• CAS NO: 4783-83-9
• Molecular Formula: C₁₁H₈N₂O₃
• Molecular Weight: 216.19
• Product Categories: Heterocycle-Pyridine series
• Mol File: 4783-83-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 79-81 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 345 ºC at 760 mmHg
• Flash Point: 162.4 ºC
• Appearance: /
• Density: 1.309 g/cm³
• Vapor Pressure: 0.000126mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: 4-(P-NITROPHENOXY)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(P-NITROPHENOXY)-PYRIDINE(4783-83-9)
• EPA Substance Registry System: 4-(P-NITROPHENOXY)-PYRIDINE(4783-83-9)

Safety Data

• Hazardous Substances Data: 4783-83-9(Hazardous Substances Data)

Usage

General Description

4-(p-nitrophenoxy)-pyridine is a chemical compound that consists of a pyridine ring with a p-nitrophenoxy group attached at the 4-position. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 4-(P-NITROPHENOXY)-PYRIDINE is known for its wide range of biological activities, including antifungal, antibacterial, and antiviral properties. Additionally, it has been investigated for its potential use in the treatment of various diseases, such as cancer and inflammatory conditions. 4-(p-nitrophenoxy)-pyridine is a valuable building block in the development of new drugs and biologically active compounds.

InChI:InChI=1/C11H8N2O3/c14-13(15)9-1-3-10(4-2-9)16-11-5-7-12-8-6-11/h1-8H

Upstream product

• 100-02-7 4-nitro-phenol 
• 1124-31-8 potassium 4-nitrophenolate 
• 5421-92-1 1-(4-pyridyl)pyridinium chloride hydrochloride 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 626-64-2 pyridin-4-ol 
• 350-46-9 4-Fluoronitrobenzene 
• 626-61-9 4-Chloropyridine 
• 4783-86-2 4-phenoxypyridine 
• 56201-88-8 [1,4']bipyridylium; hydrobromide 

Downstream Products

• 1018833-46-9 4-(4-pyridinyloxy)aniline hydrochloride 
• 864272-27-5 C₁₃H₁₄N₄O₂ 
• 79228-85-6 1-(4-nitrophenyl)-4-pyridone 
• 102877-78-1 4-(4-pyridinyloxy)aniline 

Relevant articles and documents

Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity against VEGFR2, p38α, and B-Raf

A series of diarylurea inhibitors of the cardiac-specific kinase TNNI3K were developed to elucidate the biological function of TNNI3K and evaluate TNNI3K as a therapeutic target for the treatment of cardiovascular diseases. Utilizing a structure-based design, enhancements in kinase selectivity were engineered into the series, capitalizing on the established X-ray crystal structures of TNNI3K, VEGFR2, p38α, and B-Raf. Our efforts culminated in the discovery of an in vivo tool compound 47 (GSK329), which exhibited desirable TNNI3K potency and rat pharmacokinetic properties as well as promising kinase selectivity against VEGFR2 (40-fold), p38α (80-fold), and B-Raf (>200-fold). Compound 47 demonstrated positive cardioprotective outcomes in a mouse model of ischemia/reperfusion cardiac injury, indicating that optimized exemplars from this series, such as 47, are favorable leads for discovering novel medicines for cardiac diseases.

BENZIMIDAZOLYL DERIVATIVES

The invention relates to the novel compounds of formula (I) wherein R1, R1 , L, E, G, M, Q, U, R2, m, p and q are defined as in claim 1. The novel compounds are tyrosinkinase inhibitors, especially TIE-2 inhibitors, and Ra

SEMICARBAZIDE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.