478510-85-9 Usage
Description
[1'-13C]2'-DEOXYURIDINE, also known as 2'-Deoxyuridine-1’-13C, is an isotope-labeled analogue of 2'-Deoxyuridine (D288010), which is a derivative of uridine (U829910). [1'-13C]2'-DEOXYURIDINE is characterized by the presence of a 13C isotope at the 1' position, which distinguishes it from the standard 2'-Deoxyuridine. It is utilized in various applications due to its unique properties and potential therapeutic effects.
Uses
Used in Pharmaceutical Applications:
[1'-13C]2'-DEOXYURIDINE is used as a therapeutic agent for treating a range of medical conditions, including allergies, cancer, infections, and autoimmune diseases. The isotope labeling allows for better tracking and understanding of the compound's behavior within the body, which can lead to improved treatment strategies and outcomes.
Used in Research and Development:
In the field of research, [1'-13C]2'-DEOXYURIDINE serves as an essential tool for studying the mechanisms of action, metabolic pathways, and interactions of 2'-Deoxyuridine and its derivatives. The isotope labeling enables researchers to differentiate between the labeled compound and endogenous molecules, providing valuable insights into the biological processes involved.
Used in Diagnostic Applications:
The isotope-labeled nature of [1'-13C]2'-DEOXYURIDINE also makes it a valuable diagnostic tool. It can be used to detect and monitor the presence of specific diseases or conditions by tracking the compound's distribution and metabolism within the body. This can aid in the early detection and accurate diagnosis of various medical conditions, ultimately leading to better patient outcomes.
Used in Drug Development:
In the pharmaceutical industry, [1'-13C]2'-DEOXYURIDINE can be employed as a starting material or intermediate in the synthesis of novel therapeutic agents. The isotope labeling can help researchers identify and optimize the most effective drug candidates, potentially leading to the development of new treatments for a wide range of diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 478510-85-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,5,1 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 478510-85:
(8*4)+(7*7)+(6*8)+(5*5)+(4*1)+(3*0)+(2*8)+(1*5)=179
179 % 10 = 9
So 478510-85-9 is a valid CAS Registry Number.
478510-85-9Relevant articles and documents
One-pot two-step enzymatic coupling of pyrimidine bases to 2-deoxy-D-ribose-5-phosphate. A new strategy in the synthesis of stable isotope labeled deoxynucleosides
Ouwerkerk,Steenweg,De Ruijter,Brouwer,Van Boom,Lugtenburg,Raap
, p. 1480 - 1489 (2007/10/03)
The enzymatic synthesis of thymidine from 2-deoxy-D-ribose-5-phosphate is achieved, in a one-pot two-step reaction using phosphoribomutase (PRM) and commercially available thymidine phosphorylase (TP). In the first step the sugar-5-phosphate is enzymatically rearranged to α-2-deoxy-D-ribose-1-phosphate. Highly active PRM is easily obtained from genetically modified overproducing E. coli cells (12000 units/84 mg protein) and is used without further purification. In the second step thymine is coupled to the sugar-1-phosphate. The thermodynamically unfavorable equilibrium is shifted to the product by addition of MnCl2 to precipitate inorganic phosphate. In this way the overall yield of the β-anomeric pure nucleoside increases from 14 to 60%. In contrast to uracil, cytosine is not accepted by TP as a substrate. Therefore, 2′-deoxy-cytidine is obtained by functional group transformations of the enzymatically prepared 2′-deoxy-uridine. The method has been demonstrated by the synthesis of [2′,5′-13C2]- and [1′,2′,5′-13C3]thymidine as well as [1′,2′,5′-13C3]2′-deoxyuridine and [3′,4′-13C2]2′-deoxycytidine. In addition the nucleoside bases thymine and uracil are tetralabeled at the (1,3-15N2,2,4-13C2)-atomic positions. All compounds are prepared without any scrambling or dilution of the labeled material and are thus obtained with a very high isotope enrichment (96-99%). In combination with the methods that have been developed earlier it is concluded that each of the 13C- and 15N-positions and combination of positions of the pyrimidine deoxynucleosides can be efficiently labeled starting from commercially available and highly 13C- or 15N-enriched formaldehyde, acetaldehyde, acetic acid, potassium cyanide, methylamine hydrochloride, and ammonia.
