479543-46-9

Basic information

• Product Name: VX-702
• Synonyms: 1-(5-CarbaMoyl-6-(2,4-difluorophenyl)pyridin-2-yl)-1-(2,6-difluorophenyl)urea
• CAS NO: 479543-46-9
• Molecular Formula: C19H12F4N4O2
• Molecular Weight: 404.322
• Product Categories: MAPK
• Mol File: 479543-46-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 555.2 °C at 760 mmHg
• Flash Point: 289.6 °C
• Appearance: /
• Density: 1.503 g/cm³
• Vapor Pressure: 2.28E-12mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Store at +4°C
• CAS DataBase Reference: VX-702(CAS DataBase Reference)
• NIST Chemistry Reference: VX-702(479543-46-9)
• EPA Substance Registry System: VX-702(479543-46-9)

Safety Data

• Hazardous Substances Data: 479543-46-9(Hazardous Substances Data)

Usage

Uses

VX 702 is a p38 MAP kinase pathway inhibitor.

Biological Activity

Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (K D values are 3.7 and 17 nM respectively).

InChI:InChI=1/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 

Relevant articles and documents

SOLID FORMS OF 2-(2, 4-DIFLUOROPHENYL)-6-(1-(2,6-DIFLUOROPHENYL)UREIDO)NICOTINAMIDE

This invention relates to solid forms of 2-(2, 4-difluorophenyl)-6-(l- (2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.