480438-96-8

Basic information

• Product Name: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL CHLORIDE
• Synonyms: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL CHLORIDE;3-Bromo-4-(chloromethyl)benzotrifluoride, 2-Bromo-1-(chloromethyl)-4-(trifluoromethyl)benzene
• CAS NO: 480438-96-8
• Molecular Formula: C₈H₅BrClF₃
• Molecular Weight: 273.48
• Product Categories: Fluorine series
• Mol File: 480438-96-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 234℃
• Flash Point: 95℃
• Appearance: /
• Density: 1.639
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL CHLORIDE(480438-96-8)
• EPA Substance Registry System: 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL CHLORIDE(480438-96-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 480438-96-8(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-(trifluoromethyl)benzyl chloride is a specialty chemical compound that belongs to the category of organics. It is characterized by its molecular formula, C8H6BrClF3. 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL CHLORIDE incorporates several elements including bromine, chlorine, and fluorine, connected with carbon and hydrogen in a benzyl structure. The presence of the trifluoromethyl group and the benzyl chloride with a bromo group in the chemical structure makes it widely used in synthetic chemistry as a building block for other complex compounds. Its applications are anticipated in pharmaceuticals, agriculture, and other chemical industries. However, detailed information about its physical properties and safety measures should be strictly followed as suggested by the Material Safety Data Sheet (MSDS).

InChI:InChI=1S/C8H5BrClF3/c9-7-3-6(8(11,12)13)2-1-5(7)4-10/h1-3H,4H2

Upstream product

• 497959-33-8 (2-bromo-4-(trifluoromethyl)phenyl)methanol 

Downstream Products

• 68755-34-0 diethyl 2-(2-bromo-4-trifluoromethylbenzyl) malonate 

Relevant articles and documents

Enantiospecific Synthesis of ortho-Substituted 1,1-Diarylalkanes by a 1,2-Metalate Rearrangement/anti-SN2′ Elimination/Rearomatizing Allylic Suzuki–Miyaura Reaction Sequence

The one-pot sequential coupling of benzylamines, boronic esters, and aryl iodides has been investigated. In the presence of an N-activator, the boronate complex formed from an ortho-lithiated benzylamine and a boronic ester undergoes stereospecific 1,2-metalate rearrangement/anti-SN2′ elimination to form a dearomatized tertiary boronic ester. Treatment with an aryl iodide under palladium catalysis leads to rearomatizing γ-selective allylic Suzuki–Miyaura cross-coupling to generate 1,1-diarylalkanes. When enantioenriched α-substituted benzylamines are employed, the corresponding 1,1-diarylalkanes are formed with high stereospecificity.