48059-97-8Relevant articles and documents
The effect of vicinal difluorination on the conformation and potency of histone deacetylase inhibitors
Bhadbhade, Mohan,Daryl Ariawan, A.,Ho, Junming,Hunter, Luke,Mansour, Flora,Richardson, Nicole
supporting information, (2021/07/22)
Histone deacetylase enzymes (HDACs) are potential targets for the treatment of cancer and other diseases, but it is challenging to design isoform selective agents. In this work, we created new analogs of two established but non selective HDAC inhibitors. We decorated the central linker chains of the molecules with specifically positioned fluorine atoms in order to control the molecular conformations. The fluorinated analogs were screened against a panel of 11 HDAC isoforms, and minor differences in isoform selectivity patterns were observed.
IMPROVED OLEFIN METATHESIS CATALYSTS
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Page/Page column 41; 42, (2017/02/09)
The present invention refers to novel ruthenium-based catalysts for olefin metathesis reactions, particularly to fast initiating catalysts having stereoselective properties. In olefin metathesis reactions, the disclosed catalysts provide a high catalytic activity combined with the capability to generate higher yields of the olefin metathesis product.
The synthesis of 12-membered macrocycles containing a C1-C8 alkene unit via ring-closing metathesis
Po?gan, Franc,?tefane, Bogdan,Kiemet, Davor,Smodi?, Janez,Zupet, Rok
experimental part, p. 5081 - 5086 (2012/07/28)
Model cross and ring-closing metathesis strategies toward the C1-C8-linear carbon skeleton are presented. The introduction of a four-atom tether enables the formation of 12-membered rings in good-to-excellent yields and stereoselectivity. Furthermore, the study revealed that the cross-metathesis approach and the formation of medium ring sizes via ring-closing metathesis are much less favorable.