481-97-0

Basic information

• Product Name: PREMARIN
• Synonyms: sodium [(9s,13s,14s)-13-methyl-17-oxo-9,11,12,14,15,16-hexahydro-6h-cyclopenta[a]phenanthren-3-yl] sulfate;3-hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulphate;13-methyl-17-oxo-3-sulfooxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene;ESTRONESULPHATE;17-Oxoestra-1,3,5(10)-triene-3-ol sulfate;3-(Sulfooxy)-1,3,5(10)-estratrien-17-one;Estrone hydrogen sulfate;oestrone sulphate
• CAS NO: 481-97-0
• Molecular Formula: C₁₈H₂₂O₅S
• Molecular Weight: 350.42928
• EINECS: 235-199-5
• Mol File: 481-97-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 210 °C (decomp)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Refractive Index: 1.595
• PKA: -3.84±0.18(Predicted)
• CAS DataBase Reference: PREMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: PREMARIN(481-97-0)
• EPA Substance Registry System: PREMARIN(481-97-0)

Safety Data

• Hazardous Substances Data: 481-97-0(Hazardous Substances Data)

Usage

Uses

Estrone Sulfate is a precursor of estrogen and is a circulating steroid found in men, non-pregnant women, and post-menopausal women.

Definition

ChEBI: A steroid sulfate that is the 3-sulfate of estrone.

InChI:InChI=1/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1

Upstream product

• 53-16-7 Estrone 
• 50-28-2 estradiol 

Downstream Products

• 7280-37-7 piperazine oestrone sulphate 
• 53-16-7 Estrone 

Relevant articles and documents

Piperazine estrone sulfate preparation method

The invention relates to a high-purity estra-1,3,5(10)-triene-17-one-3-piperazine sulfate (1:1) (i.e., piperazine estrone sulfate) preparation method, which has characteristics of mild reaction conditions, simple post-treatment operation and easy impurity control, so that the quality of the prepared piperazine estrone sulfate is controllable, and the stability is high. The preparation method comprises the following main steps: 1) dissolving estrone in an organic solvent, and carrying a reaction with a sulfonating reagent to obtain estra-1,3,5(10)-triene-17-one-3-sulfate; and 2) dissolving piperazine in an organic solvent, then adding into the organic solution of the estra-1,3,5(10)-triene-17-one-3-sulfate, separating out a solid, filtering, washing, and drying to obtain the high-purity piperazine estrone sulfate product.

Production, clearence rates and metabolic fate of estradiol-17β in the plasma of the laying hen

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Steroid conjugates IV. The preparation of steroid sulfates with triethylamine-sulfur trioxide.

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