4829-64-5

Basic information

• Product Name: 2'-deoxycytidylyl-(3'-5')-thymidine
• Synonyms: 2'-deoxycytidylyl-(3'-5')-thymidine
• CAS NO: 4829-64-5
• Molecular Formula: C19H26N5O11P
• Molecular Weight: 531.410401
• Mol File: 4829-64-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.91g/cm³
• Refractive Index: 1.756
• CAS DataBase Reference: 2'-deoxycytidylyl-(3'-5')-thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-deoxycytidylyl-(3'-5')-thymidine(4829-64-5)
• EPA Substance Registry System: 2'-deoxycytidylyl-(3'-5')-thymidine(4829-64-5)

Safety Data

• Hazardous Substances Data: 4829-64-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H26N5O11P/c1-9-6-24(19(29)22-17(9)27)15-4-10(26)13(34-15)8-32-36(30,31)35-11-5-16(33-12(11)7-25)23-3-2-14(20)21-18(23)28/h2-3,6,10-13,15-16,25-26H,4-5,7-8H2,1H3,(H,30,31)(H2,20,21,28)(H,22,27,29)/t10-,11-,12+,13+,15+,16-/m0/s1

Upstream product

• 21090-30-2 3'-O-acetylthymidine 
• 80817-50-1 Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 
• 80817-48-7 N-{1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-4-methoxy-benzamide 
• 17331-53-2 3'-O-benzoylthymidine 
• 81312-43-8 5'-O-monomethoxytrityl-N-benzoyldeoxycytidine 3'-p-chlorophenyl phosphate 
• 102213-03-6 Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester 
• 140613-57-6 5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] 
• 115584-68-4 Benzoic acid (2R,3S,5R)-2-[[(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-(4-chloro-phenoxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 80817-60-3 C₅₃H₅₉ClN₅O₁₄PSi 

Relevant articles and documents

Synthesis and physicochemical studies of partially phosphate-methylated oligodeoxyribonucleotides

Partially phosphate-methylated oligodeoxyribonucleotides have been synthesized on an oxalyl-CPG derivatized support using an isopropoxyacetyl group for the protection of the exocyclic amine of the nucleic bases. Hybridization properties with the target sequence have been studied by absorption spectroscopy.

O-selective condensation using P-N bond cleavage in RNA synthesis without base protection

(Chemical Equation Presented) In RNA synthesis without base protection, a new method for O-selective condensation with more than 99% selectivity was developed by 6-nitro-HOBt-mediated cleavage of undesired P(III)-N bonds on nucleobase moieties. Moreover, we for the first time succeeded in synthesizing oligoRNAs without base protection.

O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method

Previously, O-selective phosphorylation on polymer supports in the N-unprotected phosphoramidite method could not be carried out because the amino groups of dA and dC have high reactivity toward tervalent phosphorus(III)-type phosphitylating reagents. In

Synthesis and nuclease stability of dinucleotides containing an anti conformationally constrained acyclic thymidine

Novel heterodimers containing an anti conformationally constrained acyclic thymidine were prepared and the nuclease resistance of the modified dinucleotides were studied.